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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Evaluation of a fixed combination of timolol maleate, hydrochlorothiazide and amiloride hydrochloride in the treatment of hypertension: A long-term multicentre trial.

The effect of a single daily dose of timolol, hydrochlorothiazide and amiloride hydrochloride in fixed combination (Moducren; MDS) in patients with mild to moderate essential hypertension was tested during 1978 in an open study covering 10 weeks per patient. This was subsequently extended to cover a total of 50 weeks per patient, and the results are compared. Of the patients studied during phase 1, 91,5% responded with a fall in diastolic blood pressure of 10 mmHg or more. This figure decreased to 87,5% during phase 2, but none the less remained satisfactory. A single daily dose of one tablet or less of the trial preparation proved effective in the majority of patients (75%). Adverse effects were infrequent and usually of a minor nature.[1]


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