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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cell aggregation of the marine sponge Geodia cydonium. Identification of lectin-producing cells.

A D-galactose-specific lectin, purified from the marine sponge Geodia cydonium, is present on the cell surface of mucoid cells, free choanocytes and choanocyte clusters, as revealed first, by the adhesion assay which is based on the formation of "rosettes" with erythrocytes, and second, by immunofluorescence studies. Using the same techniques no lectin could be identified on the surface of archaeocytes. Rosette formation was inhibited in the presence of 20 mM D-lactose as well as after preincubation of erythrocytes with purified lectin. Titration experiments in a hemagglutination assay showed that the highest level of extractable lectin (5% of the total protein) is found in mucoid cells, lower concentrations are determined in choanocyte clusters (0.07%), free choanocytes (0.05%) and archaeocytes (0.01%). Only the mucoid cells were found to synthesize lectin which is secreted and subsequently transferred to the cell surface of other cell types. As one consequence of the binding of the lectin to the cell surface of aggregation-deficient choanocytes or archaeocytes, the conversion of these cells to aggregation-susceptible ones is observed. These results support previous evidence that the lectin is involved in the reaggregation process of single cells in the homologous biological system.[1]


  1. Cell aggregation of the marine sponge Geodia cydonium. Identification of lectin-producing cells. Müller, W.E., Zahn, R.K., Müller, I., Kurelec, B., Uhlenbruck, G., Vaith, P. Eur. J. Cell Biol. (1981) [Pubmed]
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