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Disease relevance of Hemagglutination


High impact information on Hemagglutination

  • The sera of 9 of 24 children had antibody when tested by sensitive hemagglutination inhibition [6].
  • A passive hemagglutination method for circulating autoantibody to purified human skeletal muscle myoglobin has been developed [7].
  • Hemagglutination inhibition studies with oligosaccharides of known structure also showed that the antibody binds specifically to glycoconjugates with an alpha 1----3 terminal galactose residue [8].
  • Hapten inhibition of hemagglutination with synthetic carbohydrate receptor analogues and carbohydrate-adsorbed latex agglutination studies indicate that Gal-Gal and MS pili collectively exhibit the binding properties of the parent strain [9].
  • The specificity of the monoclonal antibodies produced by these hybridomas, one an IgM and the other an IgG3, has been defined by hemagglutination inhibition, complement fixation, and lysis of glycolipid liposomes by antibody and complement [10].

Chemical compound and disease context of Hemagglutination


Biological context of Hemagglutination


Anatomical context of Hemagglutination

  • The receptor is identified in an aqueous extract of crude P. pallidum membranes as a potent inhibitor of the hemagglutination activity of pallidin [21].
  • As determined by five independent experimental procedures (antibody and complement-mediated cytotoxicity tests, the reduction of specific antibody activity of antiserum of known titer, immunofluorescent tests, mixed hemagglutination tests, and their direct isolation), TL antigens but not Thy-1 antigens were formed by the hybrid cells [22].
  • The membrane lipid fluidity of normal human erythrocytes was modified by enrichment and depletion in cholesterol, and the expression of I and SP1 antigens was assayed by quantitative hemagglutination from 4 degrees to 24 degrees C by use of a continuous flow system [23].
  • Interestingly, infectivity of tachyzoites for human foreskin fibroblasts, cells that are commonly used to grow T. gondii in vitro, was increased by low concentrations of the sulfated glycoconjugates that inhibited hemagglutination activity (i.e. dextran sulfate and fucoidan) whereas high concentrations inhibited parasite infection [24].
  • Immunoreactivities to U1 RNP constituent proteins (70K, A, B/B', and C) were detected by immunoblots using purified HeLa cell Sm antigen, and antibody titer was determined by passive hemagglutination assay [25].

Associations of Hemagglutination with chemical compounds


Gene context of Hemagglutination

  • A highly significant positive correlation (r = 0.979; P less than 0.001) was found between anti-M Ab titers by passive hemagglutination (PH; available in 650 sera) and the corresponding average anti-TPO Ab by RIA; discrepant results were almost exclusively limited to sera with negative or low (1:100-1:400) anti-M Ab titers [31].
  • There was a positive correlation between the RA hemagglutination assay titer and B cell differentiation activity (r = 0.7438) [32].
  • Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01) [33].
  • SP-D potently inhibited hemagglutination activity of several strains of IAV as well as causing viral aggregation [34].
  • Hemagglutination was inhibited both by negatively charged phospholipids and by a recombinant fragment from rat synaptotagmin that contained only a single copy of the two internal repeats [35].

Analytical, diagnostic and therapeutic context of Hemagglutination


  1. Serological response to rubella revaccination. Serdula, M.K., Halstead, S.B., Wiebenga, N.H., Herrmann, K.L. JAMA (1984) [Pubmed]
  2. Protective activity of antibodies to exotoxin A and lipopolysaccharide at the onset of Pseudomonas aeruginosa septicemia in man. Pollack, M., Young, L.S. J. Clin. Invest. (1979) [Pubmed]
  3. Isolation and partial characterization of an epiglycanin-like glycoprotein from a new non-strain-specific subline of TA3 murine mammary adenocarcinoma. Codington, J.F., Cooper, A.G., Miller, D.K., Slayter, H.S., Brown, M.C., Silber, C., Jeanloz, R.W. J. Natl. Cancer Inst. (1979) [Pubmed]
  4. Nosocomial influenza B virus infection in the elderly. Van Voris, L.P., Belshe, R.B., Shaffer, J.L. Ann. Intern. Med. (1982) [Pubmed]
  5. Immunological cross-reactivity of antibodies to a synthetic undecapeptide analogous to the amino terminal segment of carcinoembryonic antigen, with the intact protein and with human sera. Arnon, R., Bustin, M., Calef, E., Chaitchik, S., Haimovich, J., Novik, N., Sela, M. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  6. Measles and measles immunity in children infected with human immunodeficiency virus. Krasinski, K., Borkowsky, W. JAMA (1989) [Pubmed]
  7. Circulating autoantibody against human myoglobin in polymyositis. Nishikai, M., Homma, M. JAMA (1977) [Pubmed]
  8. Human natural anti-alpha-galactosyl IgG. II. The specific recognition of alpha (1----3)-linked galactose residues. Galili, U., Macher, B.A., Buehler, J., Shohet, S.B. J. Exp. Med. (1985) [Pubmed]
  9. Mannose-sensitive and Gal-Gal binding Escherichia coli pili from recombinant strains. Chemical, functional, and serological properties. O'Hanley, P., Lark, D., Normark, S., Falkow, S., Schoolnik, G.K. J. Exp. Med. (1983) [Pubmed]
  10. Production of monoclonal antibodies specific for two distinct steric portions of the glycolipid ganglio-N-triosylceramide (asialo GM2). Young, W.W., MacDonald, E.M., Nowinski, R.C., Hakomori, S.I. J. Exp. Med. (1979) [Pubmed]
  11. Clinical significance of serum antibody responses to exotoxin A and type-specific lipopolysaccharides in patients with Pseudomonas aeruginosa infections. Pollack, M., Longfield, R.N., Karney, W.W. Am. J. Med. (1983) [Pubmed]
  12. Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. Kaludov, N., Brown, K.E., Walters, R.W., Zabner, J., Chiorini, J.A. J. Virol. (2001) [Pubmed]
  13. Herpes simplex virus type 1-induced hemagglutination: glycoprotein C mediates virus binding to erythrocyte surface heparan sulfate. Trybala, E., Svennerholm, B., Bergström, T., Olofsson, S., Jeansson, S., Goodman, J.L. J. Virol. (1993) [Pubmed]
  14. Separation of neutralizing and hemagglutination-inhibiting antibody activities and specificity of antisera to sodium dodecyl sulfate-derived polypeptides of polyoma virions. Bolen, J.B., Consigli, R.A. J. Virol. (1980) [Pubmed]
  15. Prophylactic amantadine dose and plasma concentration-effect relationships in healthy adults. Aoki, F.Y., Stiver, H.G., Sitar, D.S., Boudreault, A., Ogilvie, R.I. Clin. Pharmacol. Ther. (1985) [Pubmed]
  16. Genetic control of immune response. The dose of antigen given in aqueous solution is critical in determining which mouse strain is high responder to poly(LTyr, LGlu)-poly(LPro)--poly(LLys). Jormalainen, S., Mozes, E., Sela, M. J. Exp. Med. (1975) [Pubmed]
  17. Serological detection of variable region (Vh) subgroups of Ig heavy chains. Forre, O., Natvig, J.B., Kunkel, H.G. J. Exp. Med. (1976) [Pubmed]
  18. The enamel protein amelogenin binds to the N-acetyl-D-glucosamine-mimicking peptide motif of cytokeratins. Ravindranath, R.M., Tam, W.Y., Nguyen, P., Fincham, A.G. J. Biol. Chem. (2000) [Pubmed]
  19. A single-amino-acid substitution in polyomavirus VP1 correlates with plaque size and hemagglutination behavior. Freund, R., Garcea, R.L., Sahli, R., Benjamin, T.L. J. Virol. (1991) [Pubmed]
  20. Proteolytic activation of tick-borne encephalitis virus by furin. Stadler, K., Allison, S.L., Schalich, J., Heinz, F.X. J. Virol. (1997) [Pubmed]
  21. Identification and purification of an endogenous receptor for the lectin pallidin from Polysphondylium pallidum. Drake, D.K., Rosen, S.D. J. Cell Biol. (1982) [Pubmed]
  22. Somatic hybrid of thymus leukemia (. Liang, W., Cohen, E.P. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  23. Role of membrane lipids in cold agglutination of human erythrocytes. Flamm, M., Basu, M.K., Schachter, D., Bertles, J.F., Maniatis, A. Blood (1982) [Pubmed]
  24. A Toxoplasma lectin-like activity specific for sulfated polysaccharides is involved in host cell infection. Ortega-Barria, E., Boothroyd, J.C. J. Biol. Chem. (1999) [Pubmed]
  25. Major histocompatibility complex class II gene associations with anti-U1 small nuclear ribonucleoprotein antibody. Relationship to immunoreactivity with individual constituent proteins. Kuwana, M., Okano, Y., Kaburaki, J., Tsuji, K., Inoko, H. Arthritis Rheum. (1995) [Pubmed]
  26. Isolation and partial characterization of surface components of cell line MDA-MB-231 derived from a human metastatic breast carcinoma. Walker-Nasir, E., Codington, J.F., Jahnke, M.R., Fuller, T.C., Jeanloz, R.W. J. Natl. Cancer Inst. (1982) [Pubmed]
  27. Induction of antibodies to nuclear antigens in rabbits by immunization with hydralazine-human serum albumin conjugates. Yamauchi, Y., Litwin, A., Adams, L., Zimmer, H., Hess, E.V. J. Clin. Invest. (1975) [Pubmed]
  28. Complement sensitivity of somatic hybrids of a complement-resistant murine leukemia cell line. Liang, W., Cohen, E.P. J. Natl. Cancer Inst. (1975) [Pubmed]
  29. Lipid vesicle-cell interactions. I. Hemagglutination and hemolysis. Martin, F.J., MacDonald, R.C. J. Cell Biol. (1976) [Pubmed]
  30. A conserved residue in the tip proteins of CS1 and CFA/I pili of enterotoxigenic Escherichia coli that is essential for adherence. Sakellaris, H., Munson, G.P., Scott, J.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  31. Antithyroid peroxidase autoantibodies in thyroid diseases. Mariotti, S., Caturegli, P., Piccolo, P., Barbesino, G., Pinchera, A. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  32. Synovial fluids from patients with rheumatoid arthritis possessed B cell differentiation activity contributing to synthesis of rheumatoid factor in vitro. Kitani, A., Hara, M., Hirose, T., Norioka, K., Hirose, W., Harigai, M., Suzuki, K., Kawagoe, M., Shinmei, M., Nakamura, H. J. Rheumatol. (1987) [Pubmed]
  33. Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults. McElhaney, J.E., Herre, J.M., Lawson, M.L., Cole, S.K., Burke, B.L., Hooton, J.W. Vaccine (2004) [Pubmed]
  34. Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses. Hartshorn, K.L., Crouch, E.C., White, M.R., Eggleton, P., Tauber, A.I., Chang, D., Sastry, K. J. Clin. Invest. (1994) [Pubmed]
  35. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. Perin, M.S., Johnston, P.A., Ozcelik, T., Jahn, R., Francke, U., Südhof, T.C. J. Biol. Chem. (1991) [Pubmed]
  36. Clinical significance of anti-double-stranded DNA antibodies detected by a solid phase enzyme immunoassay. Miller, T.E., Lahita, R.G., Zarro, V.J., MacWilliam, J., Koffler, D. Arthritis Rheum. (1981) [Pubmed]
  37. Purification and properties of an N-acetylglucosamine-specific lectin from Psathyrella velutina mushroom. Kochibe, N., Matta, K.L. J. Biol. Chem. (1989) [Pubmed]
  38. Isolation and characterization of a heparin-binding domain of cellular fibronectin. Hayashi, M., Schlesinger, D.H., Kennedy, D.W., Yamada, K.M. J. Biol. Chem. (1980) [Pubmed]
  39. Characterization of elevated fibrin split products following thermal injury. Curreri, P.W., Wilterdink, M.E., Baxter, C.R. Ann. Surg. (1975) [Pubmed]
  40. A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains. Okuno, Y., Isegawa, Y., Sasao, F., Ueda, S. J. Virol. (1993) [Pubmed]
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