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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Rosette Formation

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Disease relevance of Rosette Formation

  • As indicated by rosette formation of the sensitized platelets around protein A-Sepharose beads, two quinine- and two quinidine-dependent antibodies reacted with both normal and Bernard-Soulier syndrome platelets at a high (300 microM) concentration of drug [1].
  • Sera of children with kwashiorkor containing the E rosette inhibitory substance did not inhibit in vitro rosette formations by autologous lymphocytes whereas rosette formations by homologous lymphocytes were inhibited [2].
  • In both species, regardless of gender, with > or = 3 mg/kg cisplatin treatment (lethal dose) at day 0, retinal damage characterized by the appearance of aggregations of TUNEL-positive cells scattered in the undifferentiated neuroblastic layer was seen at 24 hrs, and led to rosette formation at day 3 and 7 (retinal dysplasia) [3].
  • The ability of acute sera to inhibit rosette formation was not significantly different between 18 cerebral malaria cases and 20 controls tested [mean reduction in rosetting rate 6.1% (SD 11.5) versus 8.4% (SD 12.3), P = 0.57] [4].
  • The sera from 51 patients with schistosomiasis were studied for the presence of circulating immune complexes (IC) using two methods, inhibition of EAC rosette formation and precipitation of radio-labelled Clq [5].

High impact information on Rosette Formation

  • Addition of simple sugars to the assay mixture has little effect, but rosette formation is inhibited by a series of mannose-rich glycoproteins (yeast invertase, yeast mannans and horseradish peroxidase) [6].
  • The other downregulated both CR1 and CR2, although not as efficiently as 7G6, and was unable to inhibit EC3d rosette formation [7].
  • IgG preparations from the serum of some P. falciparum-immune donors and heparin inhibited rosette formation [8].
  • In the present study using mouse serum-induced thioglycollate-elicited peritoneal M phi (TPM) as a model system for SER expression, mAb SER-4 IgG2a completely blocked rosette formation at 1 microgram/ml [9].
  • Pretreatment of RBMM with trypsin prevented rosette formation, but neuraminidase enhanced it [10].

Chemical compound and disease context of Rosette Formation


Biological context of Rosette Formation


Anatomical context of Rosette Formation


Associations of Rosette Formation with chemical compounds


Gene context of Rosette Formation

  • CD2(+) HMC-1 cells were found to form spontaneous aggregates and rosettes with sheep erythrocytes in excess over CD2(-) cells, and a T11-1 antibody inhibited both the aggregation and rosette formation [29].
  • Interestingly, inhibition of the p38 pathway also resulted in a complete blockade of IgA rosette formation [30].
  • Analysis of the effects of the inhibitors on rosette formation between human eosinophils and IgA- or IgG-coated beads revealed that activation of MEK was not required for IgA binding after priming with IL-4 or IL-5 [30].
  • This fact indicates that the new rosette-forming receptor is different from CR1 in accordance with the lack of rosette formation of Raji cells with EAC43 [31].
  • C3 receptors isolated from human erythrocytes inhibited the new rosette formation, while they did not inhibit the rosette formation of Daudi cells via CR2, indicating that the new rosette-forming receptor is different from CR2 [31].

Analytical, diagnostic and therapeutic context of Rosette Formation

  • Immunoblotting analyses showed that laminin B1 and B2 chains were constitutively expressed, whereas a fully assembled form of laminin and type IV collagen appeared only after spheroid development, suggesting that these ECM components play a morphogenetically important role in rosette formation [28].
  • The compositions of both the original and the modified lymphocyte populations were determined by (a) viability counting following treatment with antisera and complement, (b) direct and indirect immunofluorescence, (c) antibody-coated erythrocyte rosette formation, and (d) response to thymus- and bone marrow-derived cell mitogens [32].
  • To avoid rosette formation (aggregation), which would preclude crystallization, this hydrophobic tail was removed from a membrane-free form of HN by proteolytic digestion [33].
  • The presence of Fc receptors, but not C3 receptors, on human and bovine spermatozoa was shown by sperm-induced rosette formation of antibody-treated ox erythrocytes and by immunofluorescence of aggregated human gammaglobulin (AHG) treated spermatozoa [34].
  • Enhancement in FCS and 10% BSA occurred after 1 day, but not 2 or more days, of storage at 4 degrees C, but was not seen when cells were stored at 37 degrees C. Rosette formation was about doubled by centrifugation of lymphocytes through BSA gradients prior to rosette tests; centrifugation through NaM gradients had no such effect [35].


  1. Quinine- and quinidine platelet antibodies can react with GPIIb/IIIa. Christie, D.J., Mullen, P.C., Aster, R.H. Br. J. Haematol. (1987) [Pubmed]
  2. The occurrence and properties of E rosette inhibitory substance in the sera of malnourished children. Salimonu, L.S., Johnson, A.O., Williams, A.I., Adeleye, G.I., Osunkoya, B.O. Clin. Exp. Immunol. (1982) [Pubmed]
  3. Retinal damage induced by cisplatin in neonatal rats and mice. Yang, J., Yoshizawa, K., Shikata, N., Kiyozuka, Y., Senzaki, H., Tsubura, A. Curr. Eye Res. (2000) [Pubmed]
  4. Human cerebral malaria: lack of significant association between erythrocyte rosetting and disease severity. al-Yaman, F., Genton, B., Mokela, D., Raiko, A., Kati, S., Rogerson, S., Reeder, J., Alpers, M. Trans. R. Soc. Trop. Med. Hyg. (1995) [Pubmed]
  5. A study of the presence of circulating immune complexes in schistosomiasis. Smith, M.D., Verroust, P.J., Morel-Maroger, L., Geniteau, M., CouLaud, J.P. Trans. R. Soc. Trop. Med. Hyg. (1977) [Pubmed]
  6. Teratocarcinoma stem cells have a cell surface carbohydrate-binding component implicated in cell-cell adhesion. Grabel, L.B., Rosen, S.D., Martin, G.R. Cell (1979) [Pubmed]
  7. In vivo inhibition of the antibody response by a complement receptor-specific monoclonal antibody. Heyman, B., Wiersma, E.J., Kinoshita, T. J. Exp. Med. (1990) [Pubmed]
  8. Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes. Udomsangpetch, R., Wåhlin, B., Carlson, J., Berzins, K., Torii, M., Aikawa, M., Perlmann, P., Wahlgren, M. J. Exp. Med. (1989) [Pubmed]
  9. Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. Crocker, P.R., Gordon, S. J. Exp. Med. (1989) [Pubmed]
  10. Properties and distribution of a lectin-like hemagglutinin differentially expressed by murine stromal tissue macrophages. Crocker, P.R., Gordon, S. J. Exp. Med. (1986) [Pubmed]
  11. A discussion of anti-Aspergillus niger glucose oxidase monoclonal antibody reactivity to red blood cells of several species. Kojima, T., Nagata, H., Tokunaga, Y., Sano, M., Sasanabe, R., Suzumura, K., Kanemitsu, T., Naruse, T. Nagoya journal of medical science. (2000) [Pubmed]
  12. Study of spontaneous rosette formation and changes of sialic acid content in the surface glycoproteins of macrophages induced by hamster transplantable melanomas. Kozłowska, K., Zurawska-Czupa, B. Experimental pathology. (1985) [Pubmed]
  13. Subnormal inhibition of active E rosette formation by isoproterenol in bronchial asthma. Lee, C.F., Han, S.H. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi (1980) [Pubmed]
  14. Lymphocyte changes in favism: in vitro evidence of a modifying effect of bilirubin and hemoglobin on T-lymphocyte receptors. Schilirò, G., Sciotto, A., Russo, A., Bottaro, G., Minniti, C., Musumeci, S., Russo, G. Acta Haematol. (1983) [Pubmed]
  15. Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus. Iida, K., Mornaghi, R., Nussenzweig, V. J. Exp. Med. (1982) [Pubmed]
  16. Detection of nerve growth factor binding sites on neuroblastoma cells by rosette formation. Revoltella, R., Bosman, C., Bertolini, L. Cancer Res. (1975) [Pubmed]
  17. Development of functional complement receptors during in vitro maturation of human monocytes into macrophages. Newman, S.L., Musson, R.A., Henson, P.M. J. Immunol. (1980) [Pubmed]
  18. Size and charge heterogeneity of murine IgG-binding factors (IgG-BF). Blank, U., Fridman, W.H., Daëron, M., Galinha, A., Moncuit, J., Néauport-Sautès, C. J. Immunol. (1986) [Pubmed]
  19. Role of MacMARCKS in integrin-dependent macrophage spreading and tyrosine phosphorylation of paxillin. Li, J., Zhu, Z., Bao, Z. J. Biol. Chem. (1996) [Pubmed]
  20. Interaction of target cell-bound C3bi and C3d with human lymphocyte receptors. Enhancement of antibody-mediated cellular cytotoxicity. Perlmann, H., Perlmann, P., Schreiber, R.D., Müller-Eberhard, H.J. J. Exp. Med. (1981) [Pubmed]
  21. Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions. Fischer, A., Seger, R., Durandy, A., Grospierre, B., Virelizier, J.L., Le Deist, F., Griscelli, C., Fischer, E., Kazatchkine, M., Bohler, M.C. J. Clin. Invest. (1985) [Pubmed]
  22. Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule. Lamarre, D., Capon, D.J., Karp, D.R., Gregory, T., Long, E.O., Sékaly, R.P. EMBO J. (1989) [Pubmed]
  23. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Seed, B., Aruffo, A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. Surface markers of human eosinophils. Gupta, S., Ross, G.D., Good, R.A., Siegal, F.P. Blood (1976) [Pubmed]
  25. The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody. Hünig, T. J. Exp. Med. (1985) [Pubmed]
  26. Rosette formation between human lymphocytes and sheep erythrocytes. Inhibition of rosette formation by specific glycopeptides. Boldt, D.H., Armstrong, J.P. J. Clin. Invest. (1976) [Pubmed]
  27. Monocyte-platelet interaction in immune and nonimmune thrombocytopenia. Saleh, M.N., Moore, D.L., Lee, J.Y., LoBuglio, A.F. Blood (1989) [Pubmed]
  28. Neural rosette formation within in vitro spheroids of a clonal human teratocarcinoma cell line, PA-1/NR: role of extracellular matrix components in the morphogenesis. Kawata, M., Sekiya, S., Kera, K., Kimura, H., Takamizawa, H. Cancer Res. (1991) [Pubmed]
  29. Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells. Schernthaner, G.H., Jordan, J.H., Ghannadan, M., Agis, H., Bevec, D., Nuñez, R., Escribano, L., Majdic, O., Willheim, M., Worda, C., Printz, D., Fritsch, G., Lechner, K., Valent, P. Blood (2001) [Pubmed]
  30. Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils. Bracke, M., Coffer, P.J., Lammers, J.W., Koenderman, L. J. Immunol. (1998) [Pubmed]
  31. Complement receptors on Raji cells. The presence of a new type of C3 receptor. Okuda, T., Tachibana, T. Immunology (1980) [Pubmed]
  32. Stimulation of thymus- and bone marrow-derived lymphocytes by tumor cells in culture. Burk, M.W., Yu, S., Burk, K.R., McKhann, C.F. Cancer Res. (1977) [Pubmed]
  33. Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus. Thompson, S.D., Laver, W.G., Murti, K.G., Portner, A. J. Virol. (1988) [Pubmed]
  34. Demonstration of IgG Fc receptors on spermatozoa and their utilization for the detection of circulating immune complexes in human serum. Witkin, S.S., Shahani, S.K., Gupta, S., Good, R.A., Day, N.K. Clin. Exp. Immunol. (1980) [Pubmed]
  35. Bovine lymphocytes: enhanced E-rosette formation after storage or gradient centrifugation. Higgins, D.A., Stack, M.J. Clin. Exp. Immunol. (1977) [Pubmed]
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