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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Geodia

 
 
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Disease relevance of Geodia

  • Postmitochondrial fractions from marine sponges Geodia cydonium, Tethya aurantium, Verongia aerophoba and Pellina semitubulosa activate precarcinogenic aromatic amine 2-aminoanthracene, but not precarcinogenic polycyclic aromatic hydrocarbon benzo(a)pyrene, to Salmonella typhimurium TA 98 mutagens [1].
 

High impact information on Geodia

  • We have recently shown that the aggregation factor (AF) from the sponge Geodia cydonium stimulates DNA synthesis in quiescent, dissociated cells from the same organism; this event was correlated with the release of the two second messengers: inositol trisphosphate and diacylglycerol [2].
  • A mitogenic lactose-binding lectin from the sponge Geodia cydonium [3].
  • One, termed Geodia lectin I, was purified to near homogeneity by lactose elution from a column of hog A + H coupled to Sepharose 4B [3].
  • The sialyltransferase (= glycoprotein-sialic acid transferase) was studied in the sponge Geodia cydonium, a mesozoan organism [4].
  • Presented evidences suggest that cytokeratins are bound in vitro by mammalian galectin-3 and the galectins from the sponge Geodia cydonium via their type II carbohydrate recognition domains, whose highest binding affinity is directed towards terminal alpha-N-acetylgalactosamine-bearing glycans with the general sequence GalNAcalpha1-3Gal(NAc)beta [5].
 

Biological context of Geodia

  • Expression of the human XPB/ERCC-3 excision repair gene-homolog in the sponge Geodia cydonium after exposure to ultraviolet radiation [6].
  • The assessment of several parameters related to the biotransformation of mutagens/carcinogens showed that the metabolic machinery of sponge medulla cells is mainly oriented towards detoxification, with some differences depending on species (Geodia cydonium or Tethya aurantium) [7].
  • Control of L5178y cell growth by the galactose-specific lectin from Geodia cydonium [8].
  • Using the marine sponge Geodia cydonium we showed that during the initial phase of cell-cell contact the AF causes a rapid stimulation of the phosphatidylinositol pathway, resulting in an activation of protein kinase C and a subsequent phosphorylation of DNA topoisomerase II [9].
 

Associations of Geodia with chemical compounds

  • Collagen, isolated from the sponge Geodia cydonium in the absence of denaturing agents, had the typical amino acid composition and was associated with the carbohydrates galactose and glucose [10].
  • We demonstrate that the cells of the sponge Geodia cydonium are equipped with the basic elements required for a retinoic acid (RA)-dependent response pathway; RA was identified and quantitated, the cellular RA-binding protein (CRABP) was detected and the nuclear RA receptor (RAR) was found [11].
  • We have isolated and characterized a cDNA clone encoding the alpha subunit of integrin from the marine sponge Geodia cydonium (GCINTEG) [12].
  • Experimental indication in favor of the introns-late theory: the receptor tyrosine kinase gene from the sponge Geodia cydonium [13].
  • The affinity of a lectin from the sponge Geodia cydonium (GCL-I) for multi-antennary Gal beta1-->4GlcNAc and Gal beta1-->3GalNAc ligands was studied by both the biotin/avidin-based microtiter plate lectin binding assay and the inhibition of lectin-glycoform interaction [14].
 

Gene context of Geodia

  • The galectin from Geodia cydonium (GCA) had previously been shown to be involved in regulatory mechanisms of cell sorting and adhesion during reaggregation of allogeneic sponge cells [15].
  • Cloning of the polyubiquitin cDNA from the marine sponge Geodia cydonium and its preferential expression during reaggregation of cells [16].
  • Radioimmunoprecipitation experiments revealed that the Geodia fractions contain--if at all--0.1% fibronectin or fibronectin like protein at the most [17].
  • Cloning of sponge (Geodia cydonium) and tunicate (Botryllus schlosseri) proteasome subunit epsilon (PRCE): implications about the vertebrate MHC-encoded homologue LMP7 (PRCC) [18].
  • Homologous cells (Geodia archaeocytes) were determined to attach only to those Geodia collagen substrates that contained CAF [10].
 

Analytical, diagnostic and therapeutic context of Geodia

References

  1. Metabolism of some carcinogenic aromatic amines in four species of marine sponges. Kurelec, B., Britvić, S., Krca, S., Müller, W.E., Zahn, R.K. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1987) [Pubmed]
  2. Specific phosphorylation of proteins in pore complex-laminae from the sponge Geodia cydonium by the homologous aggregation factor and phorbol ester. Role of protein kinase C in the phosphorylation of DNA topoisomerase II. Rottmann, M., Schröder, H.C., Gramzow, M., Renneisen, K., Kurelec, B., Dorn, A., Friese, U., Müller, W.E. EMBO J. (1987) [Pubmed]
  3. A mitogenic lactose-binding lectin from the sponge Geodia cydonium. Bretting, H., Phillips, S.G., Klumpart, H.J., Kabat, E.A. J. Immunol. (1981) [Pubmed]
  4. Species-specific aggregation factor in sponges. Sialyltransferase associated with aggregation factor. Müller, W.E., Arendes, J., Kurelec, B., Zahn, R.K., Müller, I. J. Biol. Chem. (1977) [Pubmed]
  5. Novel alphaGalNAc containing glycans on cytokeratins are recognized invitro by galectins with type II carbohydrate recognition domains. Goletz, S., Hanisch, F.G., Karsten, U. J. Cell. Sci. (1997) [Pubmed]
  6. Expression of the human XPB/ERCC-3 excision repair gene-homolog in the sponge Geodia cydonium after exposure to ultraviolet radiation. Batel, R., Fafandjel, M., Blumbach, B., Schröder, H.C., Hassanein, H.M., Müller, I.M., Müller, W.E. Mutat. Res. (1998) [Pubmed]
  7. Biotransformation of genotoxic agents in marine sponges. Mechanisms and modulation. De Flora, S., Bagnasco, M., Bennicelli, C., Camoirano, A., Bojnemirski, A., Kurelec, B. Mutagenesis (1995) [Pubmed]
  8. Control of L5178y cell growth by the galactose-specific lectin from Geodia cydonium. Diehl-Seifert, B., Zahn, R.K., Uhlenbruck, G., Maidhof, A., Müller, W.E. Basic and applied histochemistry. (1985) [Pubmed]
  9. Intracellular signal transduction pathways in sponges. Müller, W.E., Ugarković, D., Gamulin, V., Weiler, B.E., Schröder, H.C. Electron Microsc. Rev. (1990) [Pubmed]
  10. Attachment of sponge cells to collagen substrata: effect of a collagen assembly factor. Diehl-Seifert, B., Kurelec, B., Zahn, R.K., Dorn, A., Jericevic, B., Uhlenbruck, G., Müller, W.E. J. Cell. Sci. (1985) [Pubmed]
  11. Modulation of myb gene expression in sponges by retinoic acid. Biesalski, H.K., Doepner, G., Tzimas, G., Gamulin, V., Schröder, H.C., Batel, R., Nau, H., Müller, W.E. Oncogene (1992) [Pubmed]
  12. On the origin of Metazoan adhesion receptors: cloning of integrin alpha subunit from the sponge Geodia cydonium. Pancer, Z., Kruse, M., Müller, I., Müller, W.E. Mol. Biol. Evol. (1997) [Pubmed]
  13. Experimental indication in favor of the introns-late theory: the receptor tyrosine kinase gene from the sponge Geodia cydonium. Gamulin, V., Skorokhod, A., Kavsan, V., Müller, I.M., Müller, W.E. J. Mol. Evol. (1997) [Pubmed]
  14. Multi-antennary Gal beta1-->4GlcNAc and Gal beta1-->3GalNAc clusters as important ligands for a lectin isolated from the sponge Geodia cydonium. Wu, J.H., Song, S.C., Chen, Y.Y., Tsai, M.C., Kabat, E.A., Wu, A.M. FEBS Lett. (1998) [Pubmed]
  15. Forssman disaccharide is the specific ligand of a galectin from the sponge Geodia cydonium but does not mediate its binding to nuclear protein np56. Hanisch, F.G., Baldus, S.E., Kümmel, T.A. Glycobiology (1996) [Pubmed]
  16. Cloning of the polyubiquitin cDNA from the marine sponge Geodia cydonium and its preferential expression during reaggregation of cells. Pfeifer, K., Frank, W., Schröder, H.C., Gamulin, V., Rinkevich, B., Batel, R., Müller, I.M., Müller, W.E. J. Cell. Sci. (1993) [Pubmed]
  17. Fibronectin is apparently not involved in species-specific reaggregation of cells from the marine sponge geodia cydonium. Conrad, J., Diehl-Seifert, B., Zahn, R.K., Uhlenbruck, G., Zimmermann, E., Müller, W.E. J. Cell. Biochem. (1982) [Pubmed]
  18. Cloning of sponge (Geodia cydonium) and tunicate (Botryllus schlosseri) proteasome subunit epsilon (PRCE): implications about the vertebrate MHC-encoded homologue LMP7 (PRCC). Pancer, Z., Scheffer, U., Müller, I., Müller, W.E. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  19. Molecular cloning of a tyrosine kinase gene from the marine sponge Geodia cydonium: a new member belonging to the receptor tyrosine kinase class II family. Schäcke, H., Schröder, H.C., Gamulin, V., Rinkevich, B., Müller, I.M., Müller, W.E. Mol. Membr. Biol. (1994) [Pubmed]
  20. Characterization of the trimeric, self-recognizing Geodia cydonium lectin I. Müller, W.E., Conrad, J., Schröder, C., Zahn, R.K., Kurelec, B., Dreesbach, K., Uhlenbruck, G. Eur. J. Biochem. (1983) [Pubmed]
 
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