The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Early detection and surgical treatment of esophageal carcinoma.

From 1960-1980, the technic of abrasive cytologic examination by means of a "balloon catheter" has been used to detect esophageal carcinoma in high-incidence areas with rates of positive diagnosis varying from 87.8% to 91.9%. An application of this technic in mass screenings has led to detection of a large number of very early cases of esophageal carcinoma, of which only about 50% showed positive X-ray findings and 75% showed positive endoscopic findings. Intraluminal staining with toluidine blue through a fiberoptic esophagoscope gave a positive biopsy in 83.9%. In a 16-year period from 1964 through 1979, 237 patients with Stage I esophageal carcinoma underwent surgery. The resectability rate was 100% and the operative mortality 2.5%. Pathologic study of the resected specimens showed carcinoma in situ in 84 cases (35.4%) and early infiltrative carcinoma confined to only the mucosa and submucosa in 153 cases (64.6%). The 5- and 10-year survival rates following resection were 85.9% and 55.6%, respectively. In surgery on 1,647 patients with more advanced carcinoma of the esophagus and who underwent surgery between 1958 and 1979, (resectability rate of 83.4% and a resection mortality of 4.1%), the p-TNM histopathological classification of these patients showed that 72.3% had Stage III and 8.8% had Stage IV diseases, with either extra-esophageal tumor invasion and/or regional lymph node involvements, or distant metastases. The 5-, 10- and 15-year survivals, as calculated by the number of resections were 30.3%, 21.2% and 16.2%, respectively. Analysis showed that prognosis was related to staging of the disease, the extent of tumor invasion, length of the lesion, and the presence or absence of nodal involvement.[1]


  1. Early detection and surgical treatment of esophageal carcinoma. Huang, G.J. The Japanese journal of surgery. (1981) [Pubmed]
WikiGenes - Universities