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MeSH Review

Carcinoma in Situ

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Disease relevance of Carcinoma in Situ


High impact information on Carcinoma in Situ

  • BRCA1 mRNA levels are markedly decreased during the transition from carcinoma in situ to invasive cancer [6].
  • These results indicate a unique role for Egr1 in regulating the transition from localized, carcinoma in situ to invasive carcinoma [7].
  • HPV16 VLP-specific IgGs were consistently detected in all women (n = 11) who were persistently HPV16 DNA positive during follow-up and whose disease ultimately progressed to CIN III (histologically diagnosed severe dysplasia or carcinoma in situ) [8].
  • The incidence of carcinoma in situ for women in the study population (38.2 per 100,000) was 21% higher than that for White women (31.5 per 100,000) or for Black women (31.2 per 100,000) in the SEER population [9].
  • These results confirm that the hyperbasophilic foci may be a population similar to carcinoma in situ or may be a direct precursor lesion of hepatocellular carcinoma [10].

Chemical compound and disease context of Carcinoma in Situ


Biological context of Carcinoma in Situ


Anatomical context of Carcinoma in Situ


Gene context of Carcinoma in Situ

  • A low level of DAD-R expression is also observed in normal testicular parenchyma and in parenchyma containing the precursor cells of this cancer, i.e., carcinoma in situ [26].
  • In contrast, a strong correlation between suprabasal expression of PCNA, a marker for proliferating cells, and dysplasia/carcinoma in situ was evident.(ABSTRACT TRUNCATED AT 400 WORDS)[24]
  • Most carcinoma-in-situ lesions appeared to gain expression of cyclin D2 but not D1 or D3, while the invasive testicular tumours showed variable positivity for cyclins D2 and D3, but rarely D1 [27].
  • Tumor infiltrating mononuclear cells from infiltrating carcinomas and carcinomas in situ expressed CD40 (10 of 10 cases), but less commonly CD40L (1 case of infiltrating lobular carcinoma, 2 cases of carcinoma in situ) [28].
  • For SCC the sequence appears to include TP53 mutant clones in normal skin; dysplasia; carcinoma in situ; and SCC [29].

Analytical, diagnostic and therapeutic context of Carcinoma in Situ


  1. A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette-Guérin for transitional-cell carcinoma of the bladder. Lamm, D.L., Blumenstein, B.A., Crawford, E.D., Montie, J.E., Scardino, P., Grossman, H.B., Stanisic, T.H., Smith, J.A., Sullivan, J., Sarosdy, M.F. N. Engl. J. Med. (1991) [Pubmed]
  2. Comparative carcinogenicity of N-butyl-N-(3-carboxypropyl)-nitrosamine and N-butyl-N-(4-hydroxybutyl)nitrosamine for the urinary bladder of (C57BL/6 X DBA/2)F1 mice. Irving, C.C., Murphy, W.M., Daniel, D.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  3. Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure. Yuan, B., Heniford, B.W., Ackermann, D.M., Hawkins, B.L., Hendler, F.J. Cancer Res. (1994) [Pubmed]
  4. Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Mohammed, S.I., Knapp, D.W., Bostwick, D.G., Foster, R.S., Khan, K.N., Masferrer, J.L., Woerner, B.M., Snyder, P.W., Koki, A.T. Cancer Res. (1999) [Pubmed]
  5. Differential expression of the zinc finger gene TCF17 in testicular tumors. Przyborski, S.A., Damjanov, I., Knowles, B.B., Ackerman, S.L. Cancer Res. (1998) [Pubmed]
  6. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Thompson, M.E., Jensen, R.A., Obermiller, P.S., Page, D.L., Holt, J.T. Nat. Genet. (1995) [Pubmed]
  7. Impaired prostate tumorigenesis in Egr1-deficient mice. Abdulkadir, S.A., Qu, Z., Garabedian, E., Song, S.K., Peters, T.J., Svaren, J., Carbone, J.M., Naughton, C.K., Catalona, W.J., Ackerman, J.J., Gordon, J.I., Humphrey, P.A., Milbrandt, J. Nat. Med. (2001) [Pubmed]
  8. Immunoglobulin G responses against human papillomavirus type 16 virus-like particles in a prospective nonintervention cohort study of women with cervical intraepithelial neoplasia. de Gruijl, T.D., Bontkes, H.J., Walboomers, J.M., Schiller, J.T., Stukart, M.J., Groot, B.S., Chabaud, M.M., Remmink, A.J., Verheijen, R.H., Helmerhorst, T.J., Meijer, C.J., Scheper, R.J. J. Natl. Cancer Inst. (1997) [Pubmed]
  9. Incidence of dysplasia and carcinoma of the uterine cervix in an Appalachian population. Friedell, G.H., Tucker, T.C., McManmon, E., Moser, M., Hernandez, C., Nadel, M. J. Natl. Cancer Inst. (1992) [Pubmed]
  10. DNA content of liver cell nuclei of N-2-fluorenylacetamide-induced altered foci and neoplasms in rats and human hyperplastic foci. Mori, H., Tanaka, T., Sugie, S., Takahashi, M., Williams, G.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  11. Effect of intravesical Bacillus Calmette-Guérin on detection of a urothelial differentiation antigen in exfoliated cells of carcinoma in situ of the human urinary bladder. Huffman, J.L., Fradet, Y., Cordon-Cardo, C., Herr, H.W., Pinsky, C.M., Oettgen, H.F., Old, L.J., Whitmore, W.F., Melamed, M.R. Cancer Res. (1985) [Pubmed]
  12. Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats. Hirose, M., Fukushima, S., Kurata, Y., Tsuda, H., Tatematsu, M., Ito, N. Cancer Res. (1988) [Pubmed]
  13. Cellular binding proteins for vitamin A in the normal human uterine cervix and in dysplasias. Palan, P.R., Romney, S.L. Cancer Res. (1979) [Pubmed]
  14. Porphyrin-sensitized photoinactivation of human cells in vitro. Moan, J., Johannessen, J.V., Christensen, T., Espevik, T., McGhie, J.B. Am. J. Pathol. (1982) [Pubmed]
  15. Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium. Lindberg, K., Rheinwald, J.G. Am. J. Pathol. (1989) [Pubmed]
  16. Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder. Cheng, J., Huang, H., Pak, J., Shapiro, E., Sun, T.T., Cordon-Cardo, C., Waldman, F.M., Wu, X.R. Cancer Res. (2003) [Pubmed]
  17. Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Hartmann, A., Schlake, G., Zaak, D., Hungerhuber, E., Hofstetter, A., Hofstaedter, F., Knuechel, R. Cancer Res. (2002) [Pubmed]
  18. X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status. Looijenga, L.H., Gillis, A.J., van Gurp, R.J., Verkerk, A.J., Oosterhuis, J.W. Am. J. Pathol. (1997) [Pubmed]
  19. Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome. Ahmed, S.F., Cheng, A., Dovey, L., Hawkins, J.R., Martin, H., Rowland, J., Shimura, N., Tait, A.D., Hughes, I.A. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  20. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Chan, M.W., Chan, L.W., Tang, N.L., Tong, J.H., Lo, K.W., Lee, T.L., Cheung, H.Y., Wong, W.S., Chan, P.S., Lai, F.M., To, K.F. Clin. Cancer Res. (2002) [Pubmed]
  21. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Kim, G.E., Bae, H.I., Park, H.U., Kuan, S.F., Crawley, S.C., Ho, J.J., Kim, Y.S. Gastroenterology (2002) [Pubmed]
  22. p53 protein accumulates frequently in early bronchial neoplasia. Bennett, W.P., Colby, T.V., Travis, W.D., Borkowski, A., Jones, R.T., Lane, D.P., Metcalf, R.A., Samet, J.M., Takeshima, Y., Gu, J.R. Cancer Res. (1993) [Pubmed]
  23. E-cadherin expression determines the mode of replacement of normal urothelium by human bladder carcinoma cells. Rebel, J.M., Thijssen, C.D., Vermey, M., Delouvée, A., Zwarthoff, E.C., Van der Kwast, T.H. Cancer Res. (1994) [Pubmed]
  24. Markers for dysplasia of the upper aerodigestive tract. Suprabasal expression of PCNA, p53, and CK19 in alcohol-fixed, embedded tissue. Coltrera, M.D., Zarbo, R.J., Sakr, W.A., Gown, A.M. Am. J. Pathol. (1992) [Pubmed]
  25. Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors. Hoei-Hansen, C.E., Nielsen, J.E., Almstrup, K., Sonne, S.B., Graem, N., Skakkebaek, N.E., Leffers, H., Rajpert-De Meyts, E. Clin. Cancer Res. (2004) [Pubmed]
  26. Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. Zafarana, G., Gillis, A.J., van Gurp, R.J., Olsson, P.G., Elstrodt, F., Stoop, H., Millán, J.L., Oosterhuis, J.W., Looijenga, L.H. Cancer Res. (2002) [Pubmed]
  27. D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy. Bartkova, J., Rajpert-de Meyts, E., Skakkebaek, N.E., Bartek, J. J. Pathol. (1999) [Pubmed]
  28. Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer. Tong, A.W., Papayoti, M.H., Netto, G., Armstrong, D.T., Ordonez, G., Lawson, J.M., Stone, M.J. Clin. Cancer Res. (2001) [Pubmed]
  29. Skin precancer. Brash, D.E., Pontén, J. Cancer Surv. (1998) [Pubmed]
  30. p53 gene mutations are common in uterine serous carcinoma and occur early in their pathogenesis. Tashiro, H., Isacson, C., Levine, R., Kurman, R.J., Cho, K.R., Hedrick, L. Am. J. Pathol. (1997) [Pubmed]
  31. Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin. Ren, Z.P., Ahmadian, A., Pontén, F., Nistér, M., Berg, C., Lundeberg, J., Uhlén, M., Pontén, J. Am. J. Pathol. (1997) [Pubmed]
  32. Inhibition of cyclin D expression in human breast carcinoma cells by retinoids in vitro. Zhou, Q., Stetler-Stevenson, M., Steeg, P.S. Oncogene (1997) [Pubmed]
  33. Intravesical bacillus Calmette-Guèrin for the treatment of superficial bladder cancer in renal transplant patients. Palou, J., Angerri, O., Segarra, J., Caparrós, J., Guirado, L., Diaz, J.M., Salvador-Bayarri, J., Villavicencio-Mavrich, H. Transplantation (2003) [Pubmed]
  34. Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. House, M.G., Guo, M., Iacobuzio-Donahue, C., Herman, J.G. Carcinogenesis (2003) [Pubmed]
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