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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mass Screening

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Disease relevance of Mass Screening


Psychiatry related information on Mass Screening


High impact information on Mass Screening

  • Capillary blood glucose in mass screening for diabetes [7].
  • Through mass screening of newborn infants, we identified a novel and prevalent GALK variant (designated here as the "Osaka" variant) associated with an A198V mutation in three infants with mild GALK deficiency [8].
  • During the first year of mass screening for alpha1 antitrypsin deficiency, 108,000 newborn Swedish infants were examined [9].
  • Because Wee1 kinase is crucial in maintaining G(2) arrest through its inhibitory phosphorylation of Cdc2, we developed a high-throughput mass screening assay and used it to screen chemical library for Wee1 inhibitors [10].
  • Phylogenic analysis based on sequencing analysis of multiple HDV strains isolated from sera of patients is not convenient for mass screening in routine laboratories [11].

Chemical compound and disease context of Mass Screening


Biological context of Mass Screening


Anatomical context of Mass Screening


Associations of Mass Screening with chemical compounds

  • Mass screening for 6-month-old infants was performed by qualitative assessment of urinary vanillylmandelic acid (VMA) from June 1981 to September 1989 and by quantitative measurement of VMA/creatinine (Cre) and homovanillic acid (HVA)/Cre from October 1989 to December 1992 [26].
  • From 1991 to 1994, about 4,500,000 infants underwent CAH mass screening in Japan. During this period, we identified by screening 2 siblings and 2 unrelated patients who had mild elevation of serum 17-hydroxyprogesterone levels at 5 days of age, but who revealed no symptoms of CAH [27].
  • Results demonstrated the prognostic significance of serum creatinine in a community-based mass screening [5].
  • As part of a program to develop dopamine D4 antagonists for the treatment of schizophrenia, we discovered a series of 6- and 7-(phenylpiperazinyl)- and -(phenylpiperidinyl)methylbenzoxazinones through mass screening of our compound library [28].
  • We found this application to be successful and practical for mass screening of dioxin exposure in clinical samples [29].

Gene context of Mass Screening

  • Initial mass screening and subsequent SAR studies have identified 6b (PD164387) as a potent, selective, and orally active COX-2 inhibitor [30].
  • CONCLUSIONS: The quantitative Beutler test can provide precise GALT activity in newborn mass screening, and can take into consideration the influence of high temperature and humidity, duration between sampling and testing, and anemia [31].
  • High levels of Nbla03145/ECEL1 expression were significantly correlated with a younger age (p=0.0005), lower stages (p=0.0019), high level of TrkA expression (p</=0.00005), a single copy of MYCN (p<0.00005) and the tumors found by mass screening (p<0.00005) [32].
  • We examined serum NM23-H1 protein levels in 217 patients with neuroblastoma, including 131 found by mass-screening and 86 found clinically by an enzyme-linked immunosorbent assay, and determined the association between levels of this protein, and known prognostic factors or the clinical outcome [33].
  • Here we present the results of a study of six affected Romani families from Bulgaria, where index patients with galactokinase deficiency have been detected by the mass screening [34].

Analytical, diagnostic and therapeutic context of Mass Screening


  1. Age trends of lung cancer stage at diagnosis. Implications for lung cancer screening in the elderly. O'Rourke, M.A., Feussner, J.R., Feigl, P., Laszlo, J. JAMA (1987) [Pubmed]
  2. Mass screening for neuroblastoma in infants in Japan. Interim report of a mass screening study group. Sawada, T., Hirayama, M., Nakata, T., Takeda, T., Takasugi, N., Mori, T., Maeda, K., Koide, R., Hanawa, Y., Tsunoda, A. Lancet (1984) [Pubmed]
  3. Cumulative probability of PSA increase above 4.0 NG/ML in population-based screening for prostate cancer. Ito, K., Yamamoto, T., Ohi, M., Takechi, H., Kurokawa, K., Suzuki, K., Yamanaka, H. Int. J. Cancer (2004) [Pubmed]
  4. alpha1-Fetoprotein measurement in blood spotted on paper: discriminating test for hereditary tyrosinemia in neonatal mass screening. Grenier, A., Bélanger, L., Laberge, C. Clin. Chem. (1976) [Pubmed]
  5. Risk factors of end-stage renal disease and serum creatinine in a community-based mass screening. Iseki, K., Ikemiya, Y., Fukiyama, K. Kidney Int. (1997) [Pubmed]
  6. Cholesterol screening in childhood: results of a 9-year follow-up study in Swiss and Italian children in Switzerland. Mohler, B., Ackermann-Liebrich, U., Steffen, T., Staehelin, H.B. Sozial- und Präventivmedizin. (1996) [Pubmed]
  7. Capillary blood glucose in mass screening for diabetes. Krainik, F. Lancet (1984) [Pubmed]
  8. A genetic factor for age-related cataract: identification and characterization of a novel galactokinase variant, "Osaka," in Asians. Okano, Y., Asada, M., Fujimoto, A., Ohtake, A., Murayama, K., Hsiao, K.J., Choeh, K., Yang, Y., Cao, Q., Reichardt, J.K., Niihira, S., Imamura, T., Yamano, T. Am. J. Hum. Genet. (2001) [Pubmed]
  9. Mass screening of newborn Swedish infants for alpha antitrypsin deficiency. Laurell, C.B., Sveger, T. Am. J. Hum. Genet. (1975) [Pubmed]
  10. Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Wang, Y., Li, J., Booher, R.N., Kraker, A., Lawrence, T., Leopold, W.R., Sun, Y. Cancer Res. (2001) [Pubmed]
  11. Immunohistochemical differentiation of hepatitis D virus genotypes. Hsu, S.C., Syu, W.J., Ting, L.T., Wu, J.C. Hepatology (2000) [Pubmed]
  12. Dual-channel continuous-flow system for determination of phenylalanine and galactose: application to newborn screening. Hoffman, G.L., Laessig, R.H., Hassemer, D.J., Makowski, E.R. Clin. Chem. (1984) [Pubmed]
  13. Measuring thyroxine and thyrotropin simultaneously in a dried blood sample on filter paper, to screen for neonatal hypothyroidism. Nagataki, S., Ishibashi, K., Ohsawa, R., Suwa, S., Tsukamoto, N., Takahashi, T., Obara, Y., Liao, Y.Y. Clin. Chem. (1980) [Pubmed]
  14. Detection of hepatitis B virus YMDD variants using mass spectrometric analysis of oligonucleotide fragments. Hong, S.P., Kim, N.K., Hwang, S.G., Chung, H.J., Kim, S., Han, J.H., Kim, H.T., Rim, K.S., Kang, M.S., Yoo, W., Kim, S.O. J. Hepatol. (2004) [Pubmed]
  15. High cholesterol levels: is mass screening the best option? Kinlay, S. Med. J. Aust. (1988) [Pubmed]
  16. Serial measurement of urinary VMA and HVA levels from one infant: a study for neuroblastoma mass screening. Sawada, T., Numata, K., Hirata, S. J. Pediatr. Surg. (1992) [Pubmed]
  17. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Ichimiya, S., Nimura, Y., Kageyama, H., Takada, N., Sunahara, M., Shishikura, T., Nakamura, Y., Sakiyama, S., Seki, N., Ohira, M., Kaneko, Y., McKeon, F., Caput, D., Nakagawara, A. Oncogene (1999) [Pubmed]
  18. Method for identification and quantitative analysis of protein lysine methylation using matrix-assisted laser desorption/ionization--time-of-flight mass spectrometry and amino acid analysis. Yan, J.X., Sanchez, J.C., Binz, P.A., Williams, K.L., Hochstrasser, D.F. Electrophoresis (1999) [Pubmed]
  19. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series. Song, Y., Connor, D.T., Doubleday, R., Sorenson, R.J., Sercel, A.D., Unangst, P.C., Roth, B.D., Gilbertsen, R.B., Chan, K., Schrier, D.J., Guglietta, A., Bornemeier, D.A., Dyer, R.D. J. Med. Chem. (1999) [Pubmed]
  20. Risk stratification and management of sudden cardiac death: a new paradigm. El-Sherif, N., Turitto, G. J. Cardiovasc. Electrophysiol. (2003) [Pubmed]
  21. Expression of Id2 mRNA in neuroblastoma and normal ganglion. Sato, Y., Kobayashi, Y., Sasaki, H., Toyama, T., Kondo, S., Kiriyama, M., Fujii, Y. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2003) [Pubmed]
  22. Provision of platelet support for fetuses and neonates affected by severe fetomaternal alloimmune thrombocytopenia. Ranasinghe, E., Walton, J.D., Hurd, C.M., Saul, L., Smith, G., Campbell, K., Ouwehand, W.H. Br. J. Haematol. (2001) [Pubmed]
  23. Two novel glucose-6-phosphate dehydrogenase variants found in newborn mass-screening for galactosaemia. Okano, Y., Fujimoto, A., Miyagi, T., Hirono, A., Miwa, S., Niihira, S., Hirokawa, H., Yamano, Y. Eur. J. Pediatr. (2001) [Pubmed]
  24. Maternal serum alpha-fetoprotein screening in Natal. Results of over 12 000 tests. Grace, H.J., Hitzeroth, H.W., Op't Hof, J. S. Afr. Med. J. (1984) [Pubmed]
  25. Early diagnosis of cystic fibrosis in Jordanian children. Nazer, H.M. J. Trop. Pediatr. (1992) [Pubmed]
  26. Mass screening and age-specific incidence of neuroblastoma in Saitama Prefecture, Japan. Yamamoto, K., Hayashi, Y., Hanada, R., Kikuchi, A., Ichikawa, M., Tanimura, M., Yoshioka, S. J. Clin. Oncol. (1995) [Pubmed]
  27. Molecular basis of nonclassical steroid 21-hydroxylase deficiency detected by neonatal mass screening in Japan. Tajima, T., Fujieda, K., Nakae, J., Toyoura, T., Shimozawa, K., Kusuda, S., Goji, K., Nagashima, T., Cutler, G.B. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  28. A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. Belliotti, T.R., Wustrow, D.J., Brink, W.A., Zoski, K.T., Shih, Y.H., Whetzel, S.Z., Georgic, L.M., Corbin, A.E., Akunne, H.C., Heffner, T.G., Pugsley, T.A., Wise, L.D. J. Med. Chem. (1999) [Pubmed]
  29. Development of a method for dioxin analysis of small serum samples with reduced risk of volatilization. Kitamura, K., Takazawa, Y., Takei, Y., Zhou, X., Hashimoto, S., Choi, J.W., Ito, H., Morita, M. Anal. Chem. (2005) [Pubmed]
  30. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series. Song, Y., Connor, D.T., Sercel, A.D., Sorenson, R.J., Doubleday, R., Unangst, P.C., Roth, B.D., Beylin, V.G., Gilbertsen, R.B., Chan, K., Schrier, D.J., Guglietta, A., Bornemeier, D.A., Dyer, R.D. J. Med. Chem. (1999) [Pubmed]
  31. Quantitative Beutler test for newborn mass screening of galactosemia using a fluorometric microplate reader. Fujimoto, A., Okano, Y., Miyagi, T., Isshiki, G., Oura, T. Clin. Chem. (2000) [Pubmed]
  32. High expression of the novel endothelin-converting enzyme genes, Nbla03145/ECEL1alpha and beta, is associated with favorable prognosis in human neuroblastomas. Kawamoto, T., Ohira, M., Hamano, S., Hori, T., Nakagawara, A. Int. J. Oncol. (2003) [Pubmed]
  33. Clinical significance of serum NM23-H1 protein in neuroblastoma. Okabe-Kado, J., Kasukabe, T., Honma, Y., Hanada, R., Nakagawara, A., Kaneko, Y. Cancer Sci. (2005) [Pubmed]
  34. A founder mutation in the GK1 gene is responsible for galactokinase deficiency in Roma (Gypsies). Kalaydjieva, L., Perez-Lezaun, A., Angelicheva, D., Onengut, S., Dye, D., Bosshard, N.U., Jordanova, A., Savov, A., Yanakiev, P., Kremensky, I., Radeva, B., Hallmayer, J., Markov, A., Nedkova, V., Tournev, I., Aneva, L., Gitzelmann, R. Am. J. Hum. Genet. (1999) [Pubmed]
  35. The validity of spot urine samples for low-level occupational mercury exposure assessment and relationship to porphyrin and creatinine excretion rates. Martin, M.D., McCann, T., Naleway, C., Woods, J.S., Leroux, B.G., Bollen, A.M. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  36. Rapid and sensitive method for high-performance liquid chromatographic analysis of pterins in biological fluids. Antonozzi, I., Carducci, C., Vestri, L., Pontecorvi, A., Moretti, F. J. Chromatogr. (1988) [Pubmed]
  37. A simple ELISA for screening ligands of peroxisome proliferator-activated receptor-gamma. Cho, M.C., Lee, H.S., Kim, J.H., Choe, Y.K., Hong, J.T., Paik, S.G., Yoon, d.o. .Y. J. Biochem. Mol. Biol. (2003) [Pubmed]
  38. Transmission of human T cell lymphotropic virus type I by blood transfusion before and after mass screening of sera from seropositive donors. Kamihira, S., Nakasima, S., Oyakawa, Y., Moriuti, Y., Ichimaru, M., Okuda, H., Kanamura, M., Oota, T. Vox Sang. (1987) [Pubmed]
  39. Improvement in prognosis of neuroblastoma through mass population screening. Naito, H., Sasaki, M., Yamashiro, K., Takeda, T., Takasugi, N., Uchino, J., Hata, Y. J. Pediatr. Surg. (1990) [Pubmed]
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