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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Developmental changes in the cell columns and trophoblastic shell of the macaque placenta: an immunohistochemical study localizing type IV collagen, laminin, fibronectin and cytokeratins.

Developmental changes in the organization of cells and extracellular matrix in the cell columns and trophoblastic shell of macaque placentas have been examined between 37 days of gestation and term. Between 37 and 53 days a thickened basement membrane developed between the trophoblast cells of the proximal cell columns and the mesenchymal cores of contiguous anchoring villi. This layer stained strongly for type IV collagen and laminin, but weakly for fibronectin. Large "lakes" of extracellular matrix immunoreactive for all 3 of these antigens were present in the distal columns, while smaller amounts were distributed between cells of the proximal columns. During this period the trophoblast cells in the proximal shell reorganized, forming strands of cells that were separated by bands of matrix immunoreactive for type IV collagen, laminin, and fibronectin. Staining for these antigens decreased abruptly at the junction between fetal and maternal tissues. Between 66 and 104 days the thick basement membrane of the proximal columns persisted, but stained only weakly for each of the 3 extracellular matrix antigens. The large lakes of matrix in the distal columns characteristic of earlier stages gradually disappeared. The cell columns became progressively shorter and the tips of the anchoring villi became embedded in the trophoblastic shell. The matrix of the shell decreased in immunostaining intensity except for narrow rims around the trophoblast cells. Gestational ages later than 104 days showed few additional changes in the distribution of the matrix antigens or cell organization of the columns and shell. The thick basement membrane-like layer persisted to term although it continued to stain weakly for the 3 matrix antigens. The distal ends of most anchoring villi were embedded in the trophoblastic shell. The developmental changes in the organization of the columns and shell may be related to changes in placental growth rate.[1]


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