Cloning and chromosomal localization of the human ileal lipid-binding protein.
A human ileal lipid-binding protein (ILBP3) cDNA was isolated and shown to encode a 128 amino acid protein with homology to the fatty acid-binding protein gene family. The human ILBP amino acid sequence exhibited 78% identity to the rat ILBP sequence. Northern blot analysis revealed a single transcript of approx. 0.6 kb in small intestine, but no hybridization to liver, spleen, thymus, prostate, ovary, caecum, or colon. Southern blot analysis of genomic DNA from a panel of rodent-human somatic cell hybrids revealed that the human ILBP gene resides on chromosome 5 and is not linked to any other known fatty acid-binding protein family member.[1]References
- Cloning and chromosomal localization of the human ileal lipid-binding protein. Oelkers, P., Dawson, P.A. Biochim. Biophys. Acta (1995) [Pubmed]
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