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Gene Review

FABP6  -  fatty acid binding protein 6, ileal

Homo sapiens

Synonyms: Fatty acid-binding protein 6, GT, Gastrotropin, I-15P, I-BABP, ...
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Disease relevance of FABP6


High impact information on FABP6


Biological context of FABP6


Anatomical context of FABP6

  • A deficiency of the apical sodium bile acid transporter (ASBT) and ileal lipid binding protein (ILBP) in the small intestine may result in bile acid loss into the colon and might promote gallstone formation by reducing the bile acid pool and increasing the amount of hydrophobic bile salts [2].
  • To test this hypothesis, protein levels and mRNA expression of ASBT and ILBP were assessed in ileal mucosa biopsies of female gallstone carriers and controls [2].
  • PURPOSE: Fatty acid binding protein 6 (FABP6) is a cancer-related protein that acts as an intracellular transporter of bile acid in the ileal epithelium [4].
  • EXPERIMENTAL DESIGN: The expression of FABP6 mRNA was evaluated in 78 paired samples of cancer/normal tissue representing colorectal cancer cases, plus 16 adenomas, and 16 metastatic lymph nodes [4].
  • To define the functional characteristics of all eight human FABPs, viz. heart (H), brain (B), myelin (M), adipocyte (A), epidermal (E), intestinal (I), liver (L) and ileal lipid-binding protein (I-LBP), we studied their ligand specificity, their conformational stability and their immunological crossreactivity [9].

Associations of FABP6 with chemical compounds


Other interactions of FABP6


Analytical, diagnostic and therapeutic context of FABP6


  1. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Fujita, M., Fujii, H., Kanda, T., Sato, E., Hatakeyama, K., Ono, T. Eur. J. Biochem. (1995) [Pubmed]
  2. Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. Bergheim, I., Harsch, S., Mueller, O., Schimmel, S., Fritz, P., Stange, E.F. J. Lipid Res. (2006) [Pubmed]
  3. Insights into binding of fatty acids by fatty acid binding proteins. Hanhoff, T., Lücke, C., Spener, F. Mol. Cell. Biochem. (2002) [Pubmed]
  4. Fatty acid binding protein 6 is overexpressed in colorectal cancer. Ohmachi, T., Inoue, H., Mimori, K., Tanaka, F., Sasaki, A., Kanda, T., Fujii, H., Yanaga, K., Mori, M. Clin. Cancer Res. (2006) [Pubmed]
  5. Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity. Chen, F., Ananthanarayanan, M., Emre, S., Neimark, E., Bull, L.N., Knisely, A.S., Strautnieks, S.S., Thompson, R.J., Magid, M.S., Gordon, R., Balasubramanian, N., Suchy, F.J., Shneider, B.L. Gastroenterology (2004) [Pubmed]
  6. Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine. Nakahara, M., Furuya, N., Takagaki, K., Sugaya, T., Hirota, K., Fukamizu, A., Kanda, T., Fujii, H., Sato, R. J. Biol. Chem. (2005) [Pubmed]
  7. Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. Watanabe, K., Hoshi, N., Tsuura, Y., Kanda, T., Fujita, M., Fujii, H., Ono, T., Suzuki, T. Arch. Histol. Cytol. (1995) [Pubmed]
  8. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. Grober, J., Zaghini, I., Fujii, H., Jones, S.A., Kliewer, S.A., Willson, T.M., Ono, T., Besnard, P. J. Biol. Chem. (1999) [Pubmed]
  9. Ligand specificity and conformational stability of human fatty acid-binding proteins. Zimmerman, A.W., van Moerkerk, H.T., Veerkamp, J.H. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  10. Solution structure of ileal lipid binding protein in complex with glycocholate. Lücke, C., Zhang, F., Hamilton, J.A., Sacchettini, J.C., Rüterjans, H. Eur. J. Biochem. (2000) [Pubmed]
  11. A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. Tochtrop, G.P., DeKoster, G.T., Covey, D.F., Cistola, D.P. J. Am. Chem. Soc. (2004) [Pubmed]
  12. Common polymorphism in promoter of microsomal triglyceride transfer protein gene influences cholesterol, ApoB, and triglyceride levels in young african american men: results from the coronary artery risk development in young adults (CARDIA) study. Juo, S.H., Han, Z., Smith, J.D., Colangelo, L., Liu, K. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  13. New insights into the fatty acid-binding protein (FABP) family in the small intestine. Besnard, P., Niot, I., Poirier, H., Clément, L., Bernard, A. Mol. Cell. Biochem. (2002) [Pubmed]
  14. Cloning and chromosomal localization of the human ileal lipid-binding protein. Oelkers, P., Dawson, P.A. Biochim. Biophys. Acta (1995) [Pubmed]
  15. Identification of gene-selective modulators of the bile acid receptor FXR. Dussault, I., Beard, R., Lin, M., Hollister, K., Chen, J., Xiao, J.H., Chandraratna, R., Forman, B.M. J. Biol. Chem. (2003) [Pubmed]
  16. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. Landrier, J.F., Thomas, C., Grober, J., Zaghini, I., Petit, V., Poirier, H., Niot, I., Besnard, P. Biochim. Biophys. Acta (2005) [Pubmed]
  17. Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells. Kanda, T., Foucand, L., Nakamura, Y., Niot, I., Besnard, P., Fujita, M., Sakai, Y., Hatakeyama, K., Ono, T., Fujii, H. Biochem. J. (1998) [Pubmed]
  18. Comparison of total and bone-specific alkaline phosphatase in patients with nonskeletal disorder or metabolic bone diseases. Woitge, H.W., Seibel, M.J., Ziegler, R. Clin. Chem. (1996) [Pubmed]
  19. Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Tochtrop, G.P., Bruns, J.L., Tang, C., Covey, D.F., Cistola, D.P. Biochemistry (2003) [Pubmed]
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