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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Down-regulation of phospholipase C-gamma 1 during the differentiation of U937 cells.

Phospholipase C (PLC)-gamma 1 and -gamma 2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered. Northern blot analysis showed that the levels of PLC-gamma 1 and -gamma 2 transcripts were not changed. These results suggest that the expression of PLC-gamma 1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.[1]

References

  1. Down-regulation of phospholipase C-gamma 1 during the differentiation of U937 cells. Lee, Y.H., Lee, H.J., Lee, S.J., Min, D.S., Baek, S.H., Kim, Y.S., Ryu, S.H., Suh, P.G. FEBS Lett. (1995) [Pubmed]
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