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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta ( TGF-beta) superfamily, have been implicated in bone formation and the regulation of early development. To better understand the roles of BMPs in Xenopus laevis embryogenesis, we have cloned a cDNA coding for a serine/threonine kinase receptor that binds BMP-2 and BMP-4. To analyze its function, we attempted to block the BMP signaling pathway in Xenopus embryos by using a dominant-negative mutant of the BMP receptor. When the mutant receptor lacking the putative serine/threonine kinase domain was expressed in ventral blastomeres of Xenopus embryos, these blastomeres were respecified to dorsal mesoderm, eventually resulting in the formation of a secondary body axis. These findings suggest that endogenous BMP-2 and BMP-4 are involved in the dorsal-ventral specification in the embryo and that ventral fate requires induction rather than resulting from an absence of dorsal specification.[1]

References

  1. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. Suzuki, A., Thies, R.S., Yamaji, N., Song, J.J., Wozney, J.M., Murakami, K., Ueno, N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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