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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.

1. alpha-Momorcharin, a glycoprotein isolated from seeds of the bitter gourd, Momordica charantia inhibited incorporation of [3H]thymidine, [3H]leucine and [3H]uridine into P388 (mouse monocyte-macrophage), J774 (Balb/c macrophage), JAR (human placental choriocarcinoma) and sarcoma S180 cell lines. 2. The most potent inhibitory effect was exerted on P388 cells and the smallest effect on sarcoma cells. 3. alpha-Momorcharin also enhanced the tumoricidal effect of mouse macrophages on mouse mastocytomal (P815) cells.[1]

References

  1. Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines. Ng, T.B., Liu, W.K., Sze, S.F., Yeung, H.W. Gen. Pharmacol. (1994) [Pubmed]
 
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