The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Momordica

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Momordica

 

Psychiatry related information on Momordica

  • Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects [4].
 

High impact information on Momordica

  • Other supplements with positive preliminary results include Gymnema sylvestre, Aloe vera, vanadium, Momordica charantia, and nopal [5].
  • Among the indigenous fruit and vegetables, Momordica cochinchinensis (gac) fruit has been identified as having the highest beta-carotene concentration [6].
  • Plasma beta-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchinensis (gac) [6].
  • Our previous short-term experiment demonstrated that seed oil from bitter melon (Momordica charantia) (BMO), which is rich in cis(c)9, trans(t)11, t13-conjugated linolenic acid (CLN), inhibited the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) [7].
  • Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats [8].
 

Biological context of Momordica

 

Anatomical context of Momordica

 

Associations of Momordica with chemical compounds

  • We have recently described the presence of a guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] inhibitor (GCI) in an aqueous extract of the balsam pear (Momordica charantia abbreviata) [1].
  • The physicochemical properties of the galactose-specific lectin from Momordica charantia [15].
  • Effect of Momordica charantia on blood glucose level of normal and alloxan-diabetic rabbits [16].
  • Binding of 4-methylumbelliferyl beta-D-galactopyranoside to Momordica charantia lectin: fluorescence-quenching studies [17].
  • A lectin has been isolated from Momordica charantia seeds and purified to homogeneity by affinity adsorption on a cross-linked arabinogalactan column and subsequent elution with 0.1 M lactose [15].
 

Gene context of Momordica

  • Serum IFN-gamma level was markedly increased in mice inoculated with bitter gourd (Momordica charantia) juice, but IL-4 levels were not increased with any of the 34 vegetable juices [18].
  • Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract [19].
  • The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induced a significant increase in the hepatic levels of glutathione S-transferase (GST) and acid soluble sulfhydryl (-SH) after 14 or 21 days treatment in lactating dams (P < 0.01) and translactationally exposed neonates (P < 0.05) [20].
  • Elevation in the hepatic levels of cytosolic glutathione S-transferase (GST) and microsomal cytochrome b, was also observed by the topical treatment of Momordica peel, seed and whole fruit extract [21].
  • Momordica charantia trypsin inhibitor-II, which has the strongest inhibitory potency toward the amidolytic activity of factor Xa, with a Ki value 10-100 times smaller than those of other inhibitors, inhibited the activation of factor X by factor VIIa-tissue factor complex or factor IXa, while others did not [22].
 

Analytical, diagnostic and therapeutic context of Momordica

References

  1. Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata). Claflin, A.J., Vesely, D.L., Hudson, J.L., Bagwell, C.B., Lehotay, D.C., Lo, T.M., Fletcher, M.A., Block, N.L., Levey, G.S. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  2. Purification and amino acid sequence of a bitter gourd inhibitor against an acidic amino acid-specific endopeptidase of Streptomyces griseus. Ogata, F., Miyata, T., Fujii, N., Yoshida, N., Noda, K., Makisumi, S., Ito, A. J. Biol. Chem. (1991) [Pubmed]
  3. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Ahmed, I., Adeghate, E., Cummings, E., Sharma, A.K., Singh, J. Mol. Cell. Biochem. (2004) [Pubmed]
  4. Histochemical localization of glycoconjugates on microglial cells in Alzheimer's disease brain samples by using Abrus precatorius, Maackia amurensis, Momordica charantia, and Sambucus nigra lectins. Zambenedetti, P., Giordano, R., Zatta, P. Exp. Neurol. (1998) [Pubmed]
  5. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Yeh, G.Y., Eisenberg, D.M., Kaptchuk, T.J., Phillips, R.S. Diabetes Care (2003) [Pubmed]
  6. Plasma beta-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchinensis (gac). Vuong, l.e. .T., Dueker, S.R., Murphy, S.P. Am. J. Clin. Nutr. (2002) [Pubmed]
  7. Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. Kohno, H., Yasui, Y., Suzuki, R., Hosokawa, M., Miyashita, K., Tanaka, T. Int. J. Cancer (2004) [Pubmed]
  8. Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats. Raza, H., Ahmed, I., Lakhani, M.S., Sharma, A.K., Pallot, D., Montague, W. Biochem. Pharmacol. (1996) [Pubmed]
  9. Biotransformation of ferulic acid into two new dihydrotrimers by Momordica charantia peroxidase. Liu, H.L., Kong, L.Y., Takaya, Y., Niwa, M. Chem. Pharm. Bull. (2005) [Pubmed]
  10. Antioxidative effect of a chymotrypsin inhibitor from Momordica cochinchinensis (Cucurbitaceae) seeds in a primary rat hepatocyte culture. Tsoi, A.Y., Ng, T.B., Fong, W.P. J. Pept. Sci. (2005) [Pubmed]
  11. Cucurbitane triterpenoid oviposition deterrent from Momordica charantia to the leafminer, Liriomyza trifolii. Mekuria, D.B., Kashiwagi, T., Tebayashi, S., Kim, C.S. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  12. Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif. Daly, N.L., Clark, R.J., Plan, M.R., Craik, D.J. Biochem. J. (2006) [Pubmed]
  13. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Ahmed, I., Adeghate, E., Sharma, A.K., Pallot, D.J., Singh, J. Diabetes Res. Clin. Pract. (1998) [Pubmed]
  14. Guanylate cyclase activity in human leukemic and normal lymphocytes. Enzyme inhibition and cytotoxicity of plant extracts. Takemoto, D.J., Dunford, C., Vaughn, D., Kramer, K.J., Smith, A., Powell, R.G. Enzyme (1982) [Pubmed]
  15. The physicochemical properties of the galactose-specific lectin from Momordica charantia. Mazumder, T., Gaur, N., Surolia, A. Eur. J. Biochem. (1981) [Pubmed]
  16. Effect of Momordica charantia on blood glucose level of normal and alloxan-diabetic rabbits. Akhtar, M.S., Athar, M.A., Yaqub, M. Planta Med. (1981) [Pubmed]
  17. Binding of 4-methylumbelliferyl beta-D-galactopyranoside to Momordica charantia lectin: fluorescence-quenching studies. Khan, M.I., Mazumder, T., Pain, D., Gaur, N., Surolia, A. Eur. J. Biochem. (1981) [Pubmed]
  18. Induction of interferon-gamma (IFN-gamma) and T helper 1 (Th1) immune response by bitter gourd extract. Ike, K., Uchida, Y., Nakamura, T., Imai, S. J. Vet. Med. Sci. (2005) [Pubmed]
  19. Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract. Limtrakul, P., Khantamat, O., Pintha, K. Cancer Chemother. Pharmacol. (2004) [Pubmed]
  20. Postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract in the detoxication pathway of suckling neonates and lactating mice. Singh, A., Singh, S.P., Bamezai, R. Cancer Lett. (1998) [Pubmed]
  21. Momordica charantia (Bitter Gourd) peel, pulp, seed and whole fruit extract inhibits mouse skin papillomagenesis. Singh, A., Singh, S.P., Bamezai, R. Toxicol. Lett. (1998) [Pubmed]
  22. Inhibition of serine proteases of the blood coagulation system by squash family protease inhibitors. Hayashi, K., Takehisa, T., Hamato, N., Takano, R., Hara, S., Miyata, T., Kato, H. J. Biochem. (1994) [Pubmed]
  23. Preparation of highly purified momordin II without ribonuclease activity. Valbonesi, P., Barbieri, L., Bolognesi, A., Bonora, E., Polito, L., Stirpe, F. Life Sci. (1999) [Pubmed]
  24. Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet. Chaturvedi, P. Br. J. Biomed. Sci. (2005) [Pubmed]
  25. Oral hypoglycaemic activity of some medicinal plants of Sri Lanka. Karunanayake, E.H., Welihinda, J., Sirimanne, S.R., Sinnadorai, G. Journal of ethnopharmacology. (1984) [Pubmed]
  26. Carotenoid pigments in GAC fruit (Momordica cochinchinensis SPRENG). Aoki, H., Kieu, N.T., Kuze, N., Tomisaka, K., Van Chuyen, N. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
 
WikiGenes - Universities