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MeSH Review

Momordica charantia

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Disease relevance of Momordica charantia


High impact information on Momordica charantia

  • Interaction between curry ingredient (karela) and drug (chlorpropamide) [4].
  • Single crystals of ribonuclease Mc, a new class of plant ribonuclease from the seeds of the bitter gourd, were obtained from solutions of polyethylene glycol 8000 by the hanging-drop vapour diffusion method [5].
  • Ribonuclease MC1 (RNase MC1), isolated from bitter gourd seeds, is a uridine specific RNase belonging to the RNase T2 family [6].
  • The RNase NW structurally belongs to the (alpha + beta) class of proteins, having eight helices (five alpha-helices and three 3(10) helices) and six beta-strands, and its structure is highly similar to those of other plant RNases, including a uridylic acid preferential RNase MC1 from bitter gourd seeds [7].
  • Amino acid residues in ribonuclease MC1 from bitter gourd seeds which are essential for uridine specificity [8].

Biological context of Momordica charantia


Anatomical context of Momordica charantia

  • Treated cells showed significantly higher activity of acyl CoA oxidase and higher expressions of mRNA of this enzyme and fatty acid-binding protein, indicating that the bitter gourd EA extract was able to act on a natural PPARalpha signaling pathway in this cell line [10].

Associations of Momordica charantia with chemical compounds

  • The association constants for the binding of a series of ligands with a galactose-specific lectin from Momordica charantia (bitter gourd) has been determined through the ligand-induced quenching of protein fluorescence [11].
  • In the present study, we have investigated the effects of oral feeding of karela fruit juice on the hepatic cytochrome P450 (CYP) and glutathione S-transferase (GST) drug-metabolizing enzymes in the streptozotocin (STZ)-induced diabetic rat [12].
  • The cytosolic glutathione concentration was decreased in diabetic rats, and karela juice feeding normalized the effect [12].
  • HIV inhibitor from Thai bitter gourd [13].
  • Three serine proteinase inhibitors, MCTI-I, MCTI-II, and MCEI-I, were isolated from bitter gourd (Momordica charantia LINN.) seeds [14].

Gene context of Momordica charantia


Analytical, diagnostic and therapeutic context of Momordica charantia


  1. Crystallization and preliminary X-ray studies of two serine proteinase inhibitors, BGIA and BGIT, from the seeds of bitter gourd. Kondo, H., Nakanose, J., Nakagawa, A., Tanaka, I., Kimura, M., Funatsu, G. J. Struct. Biol. (1997) [Pubmed]
  2. Effect of bitter gourd (Momordica charantia) on glycaemic status in streptozotocin induced diabetic rats. Shetty, A.K., Kumar, G.S., Sambaiah, K., Salimath, P.V. Plant foods for human nutrition (Dordrecht, Netherlands) (2005) [Pubmed]
  3. Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines. Ng, T.B., Liu, W.K., Sze, S.F., Yeung, H.W. Gen. Pharmacol. (1994) [Pubmed]
  4. Interaction between curry ingredient (karela) and drug (chlorpropamide). Aslam, M., Stockley, I.H. Lancet (1979) [Pubmed]
  5. Crystallization and preliminary X-ray diffraction analysis of a plant ribonuclease from the seeds of the bitter gourd Momordica charantia. De, A., Funatsu, G. J. Mol. Biol. (1992) [Pubmed]
  6. Crystal structures of the ribonuclease MC1 mutants N71T and N71S in complex with 5'-GMP: structural basis for alterations in substrate specificity. Numata, T., Suzuki, A., Kakuta, Y., Kimura, K., Yao, M., Tanaka, I., Yoshida, Y., Ueda, T., Kimura, M. Biochemistry (2003) [Pubmed]
  7. Guanine binding site of the Nicotiana glutinosa ribonuclease NW revealed by X-ray crystallography. Kawano, S., Kakuta, Y., Kimura, M. Biochemistry (2002) [Pubmed]
  8. Amino acid residues in ribonuclease MC1 from bitter gourd seeds which are essential for uridine specificity. Numata, T., Suzuki, A., Yao, M., Tanaka, I., Kimura, M. Biochemistry (2001) [Pubmed]
  9. Regulation of apoptosis through arachidonate cascade in mammalian cells. Nishimura, K., Tsumagari, H., Morioka, A., Yamauchi, Y., Miyashita, K., Lu, S., Jisaka, M., Nagaya, T., Yokota, K. Appl. Biochem. Biotechnol. (2002) [Pubmed]
  10. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. Chao, C.Y., Huang, C.J. J. Biomed. Sci. (2003) [Pubmed]
  11. Fluorimetric studies of the binding of Momordica charantia (bitter gourd) lectin with ligands. Das, M.K., Khan, M.I., Surolia, A. Biochem. J. (1981) [Pubmed]
  12. Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats. Raza, H., Ahmed, I., Lakhani, M.S., Sharma, A.K., Pallot, D., Montague, W. Biochem. Pharmacol. (1996) [Pubmed]
  13. HIV inhibitor from Thai bitter gourd. Jiratchariyakul, W., Wiwat, C., Vongsakul, M., Somanabandhu, A., Leelamanit, W., Fujii, I., Suwannaroj, N., Ebizuka, Y. Planta Med. (2001) [Pubmed]
  14. Amino acid sequences and disulfide bridges of serine proteinase inhibitors from bitter gourd (Momordica charantia LINN.) seeds. Hara, S., Makino, J., Ikenaka, T. J. Biochem. (1989) [Pubmed]
  15. Control of life cycle of mouse adipogenic 3T3-L1 cells by dietary lipids and metabolic factors. Nishimura, K., Hatano, Y., Setoyama, T., Tsumagari, H., Miyashita, K., Lu, S., Jisaka, M., Nagaya, T., Yokota, K. Appl. Biochem. Biotechnol. (2004) [Pubmed]
  16. Induction of interferon-gamma (IFN-gamma) and T helper 1 (Th1) immune response by bitter gourd extract. Ike, K., Uchida, Y., Nakamura, T., Imai, S. J. Vet. Med. Sci. (2005) [Pubmed]
  17. Thermodynamic analysis of porphyrin binding to Momordica charantia (bitter gourd) lectin. Sultan, N.A., Maiya, B.G., Swamy, M.J. Eur. J. Biochem. (2004) [Pubmed]
  18. Isolation of a novel thermolabile heterodimeric ribonuclease with antifungal and antiproliferative activities from roots of the sanchi ginseng Panax notoginseng. Lam, S.K., Ng, T.B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  19. Isolation and characterization of a galactose binding lectin with insulinomimetic activities. From the seeds of the bitter gourd Momordica charantia (Family Cucurbitaceae). Ng, T.B., Wong, C.M., Li, W.W., Yeung, H.W. Int. J. Pept. Protein Res. (1986) [Pubmed]
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