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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Primary lupus-associated protein-losing enteropathy.

A 79-year-old native American female with a history of diabetes mellitus, but no history of hepatic or renal disease, presented with anasarca and hypoalbuminemia. Laboratory tests for fecal alpha 1-antitrypsin and an indium III- labeled plasma transferrin nuclear scan revealed a protein-losing enteropathy. A serological test was positive for antinuclear antibody in a titer of 1:1250 with a homogeneous pattern. This finding combined with low normal serum complement levels suggested the diagnosis of systemic lupus erythematosus ( SLE). This case is unusual in that protein-losing enteropathy was the only presenting symptoms. The late onset of this disease is also unusual.[1]


  1. Primary lupus-associated protein-losing enteropathy. Sunheimer, R.L., Finck, C., Mortazavi, S., McMahon, C., Pincus, M.R. Ann. Clin. Lab. Sci. (1994) [Pubmed]
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