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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription.

The expression of one of the human main type H1 histone genes (termed H1.2) appears to be regulated by several trans-acting factors. Upstream of consensus regulatory regions, such as the TATA-, CCAAT- and H1-box (AAACACA) sequences, a crucial control site is located between nucleotide positions -536 and -412 (relative to the ATG initiation site). Removal of this promoter portion causes in chloramphenicol acetyl transferase reporter gene constructs a loss of the S-phase control function of the H1.2 promoter in HeLa cells. Electrophoretic mobility-shift assay and DNase I footprinting analysis suggest that the H1-box variant AAACAGA is a potential control element within the distal promoter region.[1]

References

  1. Role of a distal promoter element in the S-phase control of the human H1.2 histone gene transcription. Eilers, A., Bouterfa, H., Triebe, S., Doenecke, D. Eur. J. Biochem. (1994) [Pubmed]
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