The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effect of low-dose cyclosporin A on systemic lupus erythematosus disease activity.

OBJECTIVE. To determine the effect of low-dose cyclosporin A (CSA) treatment on disease activity in systemic lupus erythematosus ( SLE). METHODS. All patients in the study had active disease as defined by at least the presence of a low CH50 level. Patients were initially given 3 mg/kg/day of CSA. Dosages were adjusted individually at every visit, according to both clinical and laboratory data. RESULTS. Eleven women with SLE were enrolled in the study; 10 were evaluable. After 20 weeks of CSA treatment, the mean score for disease activity on the SLE Disease Activity Index decreased significantly, from 10.6 to 3.8 (P = 0.02). The titer of antinuclear antibodies decreased in 8 patients and the level of anti-DNA antibodies decreased in 5. Side effects included hypertension (40%), hypertrichosis (30%), gingival hypertrophy (10%), and a rise in the blood urea nitrogen level. Serum creatinine levels remained unchanged. CONCLUSION. The favorable responses observed in our patients strongly suggest that low-dose CSA can reduce the disease activity of SLE.[1]

References

  1. Effect of low-dose cyclosporin A on systemic lupus erythematosus disease activity. Tokuda, M., Kurata, N., Mizoguchi, A., Inoh, M., Seto, K., Kinashi, M., Takahara, J. Arthritis Rheum. (1994) [Pubmed]
 
WikiGenes - Universities