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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm.

OBJECTIVE: To examine the effect of gossypol on human sperm in vitro and the mechanism for the effect. DESIGN: Fresh sperm ejaculates obtained from normal donors to the University of Kentucky Andrology Donor Program were exposed to gossypol. Motility was studied manually and using computer-assisted sperm analysis. In subsequent experiments, the effects of forskolin, theophylline, and cyclic adenosine monophosphate (cAMP) on sperm motion were measured. SETTING: University of Kentucky Department of Obstetrics and Gynecology Andrology Laboratory. MAIN OUTCOME MEASURES: Manual and computer-assisted measurements of sperm motility and motion characteristics. RESULTS: Gossypol inhibited sperm motility, which could be reversed partially by increasing cAMP. CONCLUSION: Gossypol exposure in vitro adversely affects sperm motility in a dose- and time-dependent manner by a cAMP-dependent mechanism.[1]

References

  1. The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. Cowart, C.L., London, S.N., Vernon, M.W., Pedigo, N.G. Fertil. Steril. (1994) [Pubmed]
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