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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Lithium levels in monkey and human brain after chronic, therapeutic, oral dosage.

Lithium levels in 32 different brain areas of 5 macacus rhesus receiving 13 mg/kg daily orally of lithium carbonate for 3-6 weeks are reported. These vary from 0.36 +/- 0.08 to 0.82 +/- 0.35 meq/kg. Levels have also been determined for most of the tissues and organs of these monkeys. They vary from 0.25 meq/kg for the carotid artery to 13.71 and 13.61 meq/liter or kg for urine or toe nails. The manic-depressive patient involved died of acute alcoholic and darvon toxicity. His whole blood level of Li was 0.86 meq/L. Two of the 16 brain levels investigated amounted to 1.49 and 1.21 meq/kg (retrosplenial cingulate gyrus and caudate nucleus). Others were as low as 0.09 meq/kg (brain stem). Li levels in a number of organs of this patient were similar to those in monkeys. Possible conclusions from these values are discussed.[1]

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