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MeSH Review

Gyrus Cinguli

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Disease relevance of Gyrus Cinguli


Psychiatry related information on Gyrus Cinguli


High impact information on Gyrus Cinguli

  • BACKGROUND: In functional brain imaging studies, exposure to cues related to cocaine, opiates, and alcohol in dependent individuals is associated with activation of the anterior cingulate gyrus, amygdala, orbitofrontal cortex, and dorsolateral prefrontal cortex [6].
  • RESULTS: From the neutral to the cigarette cue scan, heavy smokers had greater increases than nonsmoking controls in relative glucose metabolism in the perigenual anterior cingulate gyrus spanning the midline [6].
  • BACKGROUND: In functional brain imaging studies of major depressive disorder (MDD), regional abnormalities have been most commonly found in prefrontal cortex, anterior cingulate gyrus, and temporal lobe [7].
  • Moreover, these decreases in 5-HT(1A) receptor measures correlate with decreased glucose utilization as measured with 2-deoxy-2-[F-18]fluoro-d-glucose PET in the brains of ADs (standardized uptake values; globally: controls 0.89 +/- 0.04, ADs 0.72 +/- 0.04; posterior cingulate gyrus: controls 1.05 +/- 0.09, ADs 0.79 +/- 0.11) [8].
  • High levels of fmr2 mRNA were noted in the hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus [9].

Biological context of Gyrus Cinguli


Anatomical context of Gyrus Cinguli

  • GluR-6 shows a prenatal expression peak in the cingulate gyrus of the neocortex [13].
  • Compared with the resting condition, the mean rCBF was markedly increased in the contralateral sensorimotor cortex (M1-S1) and moderately increased in the contralateral cingulate gyrus and putamen in both the simple and complex motor tasks [14].
  • RESULTS: In relation to the comparison subjects, the patients with compulsive hoarding syndrome had significantly lower glucose metabolism in the posterior cingulate gyrus and cuneus, whereas the nonhoarding OCD patients had significantly higher glucose metabolism in the bilateral thalamus and caudate [15].
  • CCK4-induced anxiety was associated with 1) robust and bilateral increases in extracerebral blood flow in the vicinity of the superficial temporal artery territory and 2) CBF increases in the anterior cingulate gyrus, the claustrum-insular-amygdala region, and the cerebellar vermis [16].
  • Concentrations of the three main monoamines (5-HT, NA, and DA), their metabolites (5-HIAA, DOPAC, and HVA), and the serotonin precursor 5-hydroxy-L-tryptophan were simultaneously measured in frontal cortex, gyrus cinguli, and hypothalamus from 23 controls and 18 suicide victims [17].

Associations of Gyrus Cinguli with chemical compounds

  • Lesions of the MpFC (cingulate gyrus) significantly increased plasma levels of both adrenocorticotropin (ACTH) and corticosterone (CORT) in response to a 20 min restraint stress [18].
  • An increase in dopamine-D2 receptor binding during serotonin reuptake inhibition was found in striatum and anterior cingulate gyrus in treatment responders, but not in nonresponders [19].
  • In contrast, the NAA/Cr ratio obtained from the anterior cingulate gyrus at T1 was already reduced in bulbar-onset patients (p < 0.001), whereas no deficits were observed in limb-onset individuals in the same region [20].
  • The citalopram-induced change in cerebral metabolism was positively correlated with age in the right precuneus, right paracentral lobule, and left middle temporal gyrus and negatively correlated with age in the left anterior cingulate gyrus, right inferior and middle frontal gyri, right insula, and right inferior parietal lobule [21].
  • Significant negative correlations were found between change in local absolute glucose metabolic rate (calculated by subtracting individual data on placebo nights from that on zolpidem nights) and plasma concentration of zolpidem for the following areas: medial frontal cortex, cingulate gyrus, putamen, thalamus, and hippocampus [22].

Gene context of Gyrus Cinguli

  • After correcting for postmortem interval, significant decreases in gyrus cinguli NA, NPY and CRF, and hypothalamic DA, HVA, and 5-HIAA concentrations were obtained with advancing age [23].
  • The drug treatment produced no significant change in DA content or in the TOH to DA ratio in the prefrontal cortex and cingulate gyrus, indicating complete sparing of the mesocortical DA projections [24].
  • RESULTS: The inhibition of a prepotent tendency to respond produced markedly greater activation of the left anterior cingulate gyrus, bilateral frontopolar regions, bilateral ventrolateral prefrontal cortex, and left medial frontal gyrus in the adolescents with childhood ADHD than in the adolescents with no history of ADHD [25].
  • RESULTS: Although Ub+, alpha-synuclein-negative, and tau-negative neuronal inclusions were observed in both cognitively impaired and cognitively intact patients with ALS, their density and extent was greater among the former, with the difference greatest in the cingulate gyrus [26].
  • Total CREB protein levels were significantly higher in the cingulate gyrus during ethanol withdrawal [27].

Analytical, diagnostic and therapeutic context of Gyrus Cinguli


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  7. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Brody, A.L., Saxena, S., Stoessel, P., Gillies, L.A., Fairbanks, L.A., Alborzian, S., Phelps, M.E., Huang, S.C., Wu, H.M., Ho, M.L., Ho, M.K., Au, S.C., Maidment, K., Baxter, L.R. Arch. Gen. Psychiatry (2001) [Pubmed]
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  9. Expression of the murine homologue of FMR2 in mouse brain and during development. Chakrabarti, L., Bristulf, J., Foss, G.S., Davies, K.E. Hum. Mol. Genet. (1998) [Pubmed]
  10. 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Burnet, P.W., Eastwood, S.L., Harrison, P.J. Neuropsychopharmacology (1996) [Pubmed]
  11. Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain. Pandey, S.C., Roy, A., Xu, T., Mittal, N. J. Neurochem. (2001) [Pubmed]
  12. Cholecystokinin-B receptor gene expression in cerebellum, pre-frontal cortex and cingulate gyrus and its association with suicide. Sherrin, T., Heng, K.Y., Zhu, Y.Z., Tang, Y.M., Lau, G., Tan, C.H. Neurosci. Lett. (2004) [Pubmed]
  13. Kainate receptor gene expression in the developing rat brain. Bahn, S., Volk, B., Wisden, W. J. Neurosci. (1994) [Pubmed]
  14. Both primary motor cortex and supplementary motor area play an important role in complex finger movement. Shibasaki, H., Sadato, N., Lyshkow, H., Yonekura, Y., Honda, M., Nagamine, T., Suwazono, S., Magata, Y., Ikeda, A., Miyazaki, M. Brain (1993) [Pubmed]
  15. Cerebral glucose metabolism in obsessive-compulsive hoarding. Saxena, S., Brody, A.L., Maidment, K.M., Smith, E.C., Zohrabi, N., Katz, E., Baker, S.K., Baxter, L.R. The American journal of psychiatry. (2004) [Pubmed]
  16. Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Benkelfat, C., Bradwejn, J., Meyer, E., Ellenbogen, M., Milot, S., Gjedde, A., Evans, A. The American journal of psychiatry. (1995) [Pubmed]
  17. Serotonergic, noradrenergic, and dopaminergic measures in suicide brains. Arranz, B., Blennow, K., Eriksson, A., Månsson, J.E., Marcusson, J. Biol. Psychiatry (1997) [Pubmed]
  18. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. Diorio, D., Viau, V., Meaney, M.J. J. Neurosci. (1993) [Pubmed]
  19. In vivo evidence for the involvement of dopamine-D2 receptors in striatum and anterior cingulate gyrus in major depression. Larisch, R., Klimke, A., Vosberg, H., Löffler, S., Gaebel, W., Müller-Gärtner, H.W. Neuroimage (1997) [Pubmed]
  20. A prospective study of cognitive impairment in ALS. Strong, M.J., Grace, G.M., Orange, J.B., Leeper, H.A., Menon, R.S., Aere, C. Neurology (1999) [Pubmed]
  21. Serotonin modulation of cerebral glucose metabolism in normal aging. Goldberg, S., Smith, G.S., Barnes, A., Ma, Y., Kramer, E., Robeson, K., Kirshner, M., Pollock, B.G., Eidelberg, D. Neurobiol. Aging (2004) [Pubmed]
  22. Effects of zolpidem on local cerebral glucose metabolism during non-REM sleep in normal volunteers: a positron emission tomography study. Gillin, J.C., Buchsbaum, M.S., Valladares-Neto, D.C., Hong, C.C., Hazlett, E., Langer, S.Z., Wu, J. Neuropsychopharmacology (1996) [Pubmed]
  23. Brain monoaminergic and neuropeptidergic variations in human aging. Arranz, B., Blennow, K., Ekman, R., Eriksson, A., Månsson, J.E., Marcusson, J. Journal of neural transmission (Vienna, Austria : 1996) (1996) [Pubmed]
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  26. Cognitive impairment in sporadic ALS: a pathologic continuum underlying a multisystem disorder. Wilson, C.M., Grace, G.M., Munoz, D.G., He, B.P., Strong, M.J. Neurology (2001) [Pubmed]
  27. Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex. Pandey, S.C., Roy, A., Mittal, N. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  28. Expression of basic fibroblast growth factor mRNA after transient focal ischemia: comparison with expression of c-fos, c-jun, and hsp 70 mRNA. Iwata, A., Masago, A., Yamada, K. J. Neurotrauma (1997) [Pubmed]
  29. Distribution of methionine and leucine enkephalin neurons within the social behavior circuitry of the male Syrian hamster brain. Holt, A.G., Newman, S.W. Brain Res. (2004) [Pubmed]
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  31. Topographic organization and collateralization of the projections of the anterior and laterodorsal thalamic nuclei to cingulate areas 24 and 29 in the rat. Horikawa, K., Kinjo, N., Stanley, L.C., Powell, E.W. Neurosci. Res. (1988) [Pubmed]
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