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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Downstaging of stage C prostatic carcinoma by inductive chemo-hormonal therapy?

One hundred and three patients with clinical stage C prostatic carcinoma (palpable extra-organ extension) underwent inductive chemo-hormonal treatment followed by radical retropubic prostatectomy with pelvic lymphadenectomy. First a careful noninvasive tumor staging was performed, which included a thorough digital rectal palpation, PSA, PAP, chest X-ray, bone scan, IVP, transabdominal and transrectal ultrasonography, CT and MRI. Then inductive chemo-hormonal therapy commenced. It consisted of total androgen deprivation plus the administration of cDDP or 5-FU + calcium folinate + mitomycin. After completion of chemotherapy (i.e. 4 months later), noninvasive staging was repeated. Then radical prostatectomy was carried out, followed by histologic work-up of the specimen. Postinductive, noninvasive examinations showed clinical downstaging in 49 of the original 103 patients (47.5%). Histopathology showed confinement of the tumor to the prostate in 40 specimens (38.8%). These results prove that chemo-hormonal induction is highly effective and suggest strongly but do not prove definitely histological downstaging in a significant percentage of the patients.[1]


  1. Downstaging of stage C prostatic carcinoma by inductive chemo-hormonal therapy? Köllermann, M.W., Sprenk, P., Mühlfait, V., Kahla, H., Köllermann, J. Eur. Urol. (1993) [Pubmed]
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