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MeSH Review

Neoplasm Staging

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Disease relevance of Neoplasm Staging


Psychiatry related information on Neoplasm Staging

  • Hence, it appears that the assessment of the NSE serotest, despite its minimal value in the overall tumor staging and monitoring, might furnish the decision-making step related to the treatment of aggressive prostate cancer with an additional and powerful tool [6].

High impact information on Neoplasm Staging

  • PURPOSE: We evaluated within a single study the relationship of selected demographic, lifestyle, antecedent medical experiences, and health care access factors to cancer staging at diagnosis in Black and White breast cancer patients [1].
  • RESULTS: From the entries of patient information (age, menopausal status, comorbidity estimate) and tumor staging and characteristics (tumor size, number of positive axillary nodes, estrogen receptor status), baseline prognostic estimates are made [7].
  • Tumor staging was critical to the VHL mutation/hypermethylation detection rate in CCRCCs shown by separate evaluation of patients from medical centers in Munich, Heidelberg, and Mainz [8].
  • In addition, in a multivariate Cox regression analysis that included myb gene expression, MYCN status, age at diagnosis, and tumor staging, MYCN amplification and B-myb expression were independently associated to an increased risk (P < 0.01 and P = 0.015, respectively) [9].
  • Tumor staging with biphasic computed tomography (CT) scan or hepatic arteriography with lipiodol revealed that 101 (57%) patients had single tumor nodules and 77 (43%) patients had more than one HCC nodule [10].

Chemical compound and disease context of Neoplasm Staging


Biological context of Neoplasm Staging

  • The aims of this study were as follows: (1) to compare the use of FDG-PET and FLT-PET for tumor staging, (2) to compare the degree of FDG and FLT uptake in lung lesions, and (3) to determine the correlation between PET uptake intensity and tumor cell proliferation [14].
  • There were no differences between HCC patients with genotypes B and C regarding tumor staging by CLIP criteria and the overall median survival [15].
  • Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma [16].

Anatomical context of Neoplasm Staging

  • NM23-H1 tended to inversely relate to later recurrence or long-term survival (p=0.06), but, only tumor staging was found to be significant in predicting clinical outcome (p=0.002). nm23-H1 appears to function as a tumor suppressor for upper urinary tract cancer, however, evaluation of NM23-H1 provides limited prognostic information [17].
  • Although FDG PET is not an appropriate first-line diagnostic procedure in the detection of stomach cancer and is not helpful in tumor staging, it may play a valuable role in the detection of distant metastases, such as those of the liver, lungs, adrenal glands, ovaries, and skeleton [18].

Associations of Neoplasm Staging with chemical compounds


Gene context of Neoplasm Staging

  • Tumoral TS and tumoral DPD were not significantly influenced by tumor localization or tumor staging [24].
  • Four groups were distinguished: (a) patients being evaluated for the detection and localization of neuroendocrine tumors (n = 6), (b) tumor staging (n = 19), (c) patients being investigated to determine the SSTR status of tumor lesions (n = 11), and (d) patient follow-up studies (n = 5) [25].
  • There was no significant correlation between histological type, tumor staging and telomerase activity [26].
  • CONCLUSION: Aberrant beta-catenin expression may play an important role in the histologic differentiation and tumor staging of MEC [27].
  • In addition, the proportion of tumor relapse and tumor-induced death was more accurately predicted by PCNA and Ki-67 scoring than by tumor staging (chi 2 = 0.3159, chi 2 = 0.7186 and chi 2 = 1.9689, respectively) [28].

Analytical, diagnostic and therapeutic context of Neoplasm Staging


  1. Breast cancer: factors associated with stage at diagnosis in black and white women. Black/White Cancer Survival Study Group. Hunter, C.P., Redmond, C.K., Chen, V.W., Austin, D.F., Greenberg, R.S., Correa, P., Muss, H.B., Forman, M.R., Wesley, M.N., Blacklow, R.S. J. Natl. Cancer Inst. (1993) [Pubmed]
  2. Immunological responsiveness in patients with bladder cancer. Fahey, J.L., Brosman, S., Dorey, F. Cancer Res. (1977) [Pubmed]
  3. Improved detection of second primary cancer using integrated [18F] fluorodeoxyglucose positron emission tomography and computed tomography for initial tumor staging. Choi, J.Y., Lee, K.S., Kwon, O.J., Shim, Y.M., Baek, C.H., Park, K., Lee, K.H., Kim, B.T. J. Clin. Oncol. (2005) [Pubmed]
  4. An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo. Ito, T., Hashimoto, Y., Tanaka, E., Kan, T., Tsunoda, S., Sato, F., Higashiyama, M., Okumura, T., Shimada, Y. Clin. Cancer Res. (2006) [Pubmed]
  5. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions. Tahara, H., Kuniyasu, H., Yokozaki, H., Yasui, W., Shay, J.W., Ide, T., Tahara, E. Clin. Cancer Res. (1995) [Pubmed]
  6. Investigation on serum neurone-specific enolase in prostate cancer diagnosis and monitoring: comparative study of a multiple tumor marker assay. Tarle, M., Radoś, N. Prostate (1991) [Pubmed]
  7. Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. Ravdin, P.M., Siminoff, L.A., Davis, G.J., Mercer, M.B., Hewlett, J., Gerson, N., Parker, H.L. J. Clin. Oncol. (2001) [Pubmed]
  8. VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. Brauch, H., Weirich, G., Brieger, J., Glavac, D., Rödl, H., Eichinger, M., Feurer, M., Weidt, E., Puranakanitstha, C., Neuhaus, C., Pomer, S., Brenner, W., Schirmacher, P., Störkel, S., Rotter, M., Masera, A., Gugeler, N., Decker, H.J. Cancer Res. (2000) [Pubmed]
  9. Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification. Raschellà, G., Cesi, V., Amendola, R., Negroni, A., Tanno, B., Altavista, P., Tonini, G.P., De Bernardi, B., Calabretta, B. Cancer Res. (1999) [Pubmed]
  10. High prevalence of multinodular hepatocellular carcinoma in patients with cirrhosis attributable to multiple risk factors. Fasani, P., Sangiovanni, A., De Fazio, C., Borzio, M., Bruno, S., Ronchi, G., Del Ninno, E., Colombo, M. Hepatology (1999) [Pubmed]
  11. Immunohistochemical analysis of prostate-specific antigen does not correlate to other prognostic factors in breast cancer. Heyl, W., Wolff, J.M., Biesterfeld, S., Schröder, W., Zitzelsberger, D., Jakse, G., Rath, W. Anticancer Res. (1999) [Pubmed]
  12. p53 gene codon 72 polymorphism but not tumor necrosis factor-alpha gene is associated with prostate cancer. Wu, H.C., Chang, C.H., Chen, H.Y., Tsai, F.J., Tsai, J.J., Chen, W.C. Urologia internationalis. (2004) [Pubmed]
  13. Determination of histamine in the whole blood of colon cancer patients. Previati, M., Raspadori, A., Bertolaso, L., Parmeggiani, A., Bindini, D., Vitali, C., Lanzoni, I., Corbacella, E., Saviano, M., Fagioli, F., Blo, G., Capitani, S. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
  14. Evaluation of thoracic tumors with 18F-fluorothymidine and 18F-fluorodeoxyglucose-positron emission tomography. Yap, C.S., Czernin, J., Fishbein, M.C., Cameron, R.B., Schiepers, C., Phelps, M.E., Weber, W.A. Chest (2006) [Pubmed]
  15. Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand. Tangkijvanich, P., Mahachai, V., Komolmit, P., Fongsarun, J., Theamboonlers, A., Poovorawan, Y. World J. Gastroenterol. (2005) [Pubmed]
  16. Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma. Park, T.J., Han, S.U., Cho, Y.K., Paik, W.K., Kim, Y.B., Lim, I.K. Cancer (2001) [Pubmed]
  17. Expression of nm23-H1 in transitional cell carcinoma of the upper urinary tract. Cheng, H.L., Tong, Y.C., Tzai, T.S., Weng, C.L., Ho, C.L., Yang, W.H., Lin, J.S., Chow, N.H. Oncol. Rep. (2001) [Pubmed]
  18. CT and PET in stomach cancer: preoperative staging and monitoring of response to therapy. Lim, J.S., Yun, M.J., Kim, M.J., Hyung, W.J., Park, M.S., Choi, J.Y., Kim, T.S., Lee, J.D., Noh, S.H., Kim, K.W. Radiographics : a review publication of the Radiological Society of North America, Inc. (2006) [Pubmed]
  19. Somatostatin analogs for diagnosis and treatment of cancer. Weckbecker, G., Raulf, F., Stolz, B., Bruns, C. Pharmacol. Ther. (1993) [Pubmed]
  20. Preferential accumulation of (3)H-tetraphenylphosphonium in non-small cell lung carcinoma in mice: comparison with (99m)Tc-MIBI. Madar, I., Weiss, L., Izbicki, G. J. Nucl. Med. (2002) [Pubmed]
  21. Influence of luminal obstruction on oesophageal cancer staging using endoscopic ultrasonography. Vickers, J., Alderson, D. The British journal of surgery. (1998) [Pubmed]
  22. Prospective evaluation of a jelly-like conducting medium for catheter US probe imaging of esophageal and duodenal lesions. Soon, M.S., Soon, A., Schembre, D.B., Lin, O.S. Gastrointest. Endosc. (2005) [Pubmed]
  23. Dermatomyositis and malignancy in Tunisia: a multicenter national retrospective study of 20 cases. Mebazâa, A., Boussen, H., Nouira, R., Rokbani, L., Ben Osman-Dhahri, A., Bouaouina, N., Laouani-Kechrid, C., Louzir, B., Zahaf, A., Kamoun, M.R. J. Am. Acad. Dermatol. (2003) [Pubmed]
  24. Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity. Etienne, M.C., Chéradame, S., Fischel, J.L., Formento, P., Dassonville, O., Renée, N., Schneider, M., Thyss, A., Demard, F., Milano, G. J. Clin. Oncol. (1995) [Pubmed]
  25. An intrapatient comparison of 99mTc-EDDA/HYNIC-TOC with 111In-DTPA-octreotide for diagnosis of somatostatin receptor-expressing tumors. Gabriel, M., Decristoforo, C., Donnemiller, E., Ulmer, H., Watfah Rychlinski, C., Mather, S.J., Moncayo, R. J. Nucl. Med. (2003) [Pubmed]
  26. Analysis of telomerase activity and telomere length in bone and soft tissue tumors. Terasaki, T., Kyo, S., Takakura, M., Maida, Y., Tsuchiya, H., Tomita, K., Inoue, M. Oncol. Rep. (2004) [Pubmed]
  27. Cadherin and catenin expression in mucoepidermoid carcinoma: correlation with histopathologic grade, clinical stage, and patient outcome. Shieh, Y.S., Chang, L.C., Chiu, K.C., Wu, C.W., Lee, H.S. J. Oral Pathol. Med. (2003) [Pubmed]
  28. Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. Liu, F.S., Chen, J.T., Liu, S.C., Shih, A., Shih, R.T., Ho, E.S. Zhonghua Yi Xue Za Zhi (Taipei) (1999) [Pubmed]
  29. Imaging diagnosis. Lencioni, R., Cioni, D., Della Pina, C., Crocetti, L., Bartolozzi, C. Semin. Liver Dis. (2005) [Pubmed]
  30. Downstaging of stage C prostatic carcinoma by inductive chemo-hormonal therapy? Köllermann, M.W., Sprenk, P., Mühlfait, V., Kahla, H., Köllermann, J. Eur. Urol. (1993) [Pubmed]
  31. Clinical usefulness of fused PET/CT compared with PET alone or CT alone in nasopharyngeal carcinoma patients. Chen, Y.K., Su, C.T., Ding, H.J., Chi, K.H., Liang, J.A., Shen, Y.Y., Chen, L.K., Yeh, C.L., Liao, A.C., Kao, C.H. Anticancer Res. (2006) [Pubmed]
  32. Needle biopsy and tumor staging (TNM-system). Sinner, W.N. RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin. (1982) [Pubmed]
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