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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding.

Intravenous infusions of manose or B-hydroxybutyrate, metabolic fuels which can be oxidized by brain, abolished adrenal discharge of epinephrine in rats during insulin-induced hypoglycemia, whereas infusion of fructose, a sugar which does not cross the blood-brain barrier, did not. In contrast, increased feeding behavior during hypoglycemia was prevented both by the sugars and by B-hydroxybutyrate. Thus, while the sympathetic response during marked hypoglycemia may have been initiated by alterations in cerebal metabolism, the feeding response evidently was not, and a decrease in the utilization of glucose per se does not appear to be the critical stimulus in either case.[1]

References

  1. Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding. Stricker, E.M., Rowland, N., Saller, C.F., Friedman, M.I. Science (1977) [Pubmed]
 
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