- The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Eubanks, J.H., Puranam, R.S., Kleckner, N.W., Bettler, B., Heinemann, S.F., McNamara, J.O. Proc. Natl. Acad. Sci. U.S.A. (1993)