Gene Review:
GRIK1 - glutamate receptor, ionotropic, kainate 1
Homo sapiens
Synonyms:
EAA3, EEA3, Excitatory amino acid receptor 3, GLR5, GLUR5, ...
Swanson,
Green,
Heinemann,
Kayadjanian,
Lee,
Piña-Crespo,
Heinemann,
Dominguez,
Iyengar,
Shannon,
Bleakman,
Alt,
Arnold,
Bell,
Bleisch,
Buckmaster,
Castano,
Del Prado,
Escribano,
Filla,
Ho,
Hudziak,
Jones,
Martinez-Perez,
Mateo,
Mathes,
Mattiuz,
Ogden,
Simmons,
Stack,
Stratford,
Winter,
Wu,
Ornstein,
- The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Eubanks, J.H., Puranam, R.S., Kleckner, N.W., Bettler, B., Heinemann, S.F., McNamara, J.O. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans. Gregor, P., Reeves, R.H., Jabs, E.W., Yang, X., Dackowski, W., Rochelle, J.M., Brown, R.H., Haines, J.L., O'Hara, B.F., Uhl, G.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. Corti, C., Clarkson, R.W., Crepaldi, L., Sala, C.F., Xuereb, J.H., Ferraguti, F. J. Biol. Chem. (2003)
- LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine. Sang, C.N., Ramadan, N.M., Wallihan, R.G., Chappell, A.S., Freitag, F.G., Smith, T.R., Silberstein, S.D., Johnson, K.W., Phebus, L.A., Bleakman, D., Ornstein, P.L., Arnold, B., Tepper, S.J., Vandenhende, F. Cephalalgia : an international journal of headache. (2004)
- Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21. Gregor, P., Gaston, S.M., Yang, X., O'Regan, J.P., Rosen, D.R., Tanzi, R.E., Patterson, D., Haines, J.L., Horvitz, H.R., Uhl, G.R. Hum. Genet. (1994)
- Anthropometric indices and life style practices of the indigenous Orang Asli adults in Lembah Belum, Grik of Peninsular Malaysia. Yusof, H.M., Ching, T.S., Ibrahim, R., Lola, S. Asia Pacific journal of clinical nutrition (2007)
- Kainate receptors are involved in synaptic plasticity. Bortolotto, Z.A., Clarke, V.R., Delany, C.M., Parry, M.C., Smolders, I., Vignes, M., Ho, K.H., Miu, P., Brinton, B.T., Fantaske, R., Ogden, A., Gates, M., Ornstein, P.L., Lodge, D., Bleakman, D., Collingridge, G.L. Nature (1999)
- A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Clarke, V.R., Ballyk, B.A., Hoo, K.H., Mandelzys, A., Pellizzari, A., Bath, C.P., Thomas, J., Sharpe, E.F., Davies, C.H., Ornstein, P.L., Schoepp, D.D., Kamboj, R.K., Collingridge, G.L., Lodge, D., Bleakman, D. Nature (1997)
- Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity. Mayer, M.L. Neuron (2005)
- Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. Sander, T., Hildmann, T., Kretz, R., Fürst, R., Sailer, U., Bauer, G., Schmitz, B., Beck-Mannagetta, G., Wienker, T.F., Janz, D. Am. J. Med. Genet. (1997)
- Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1. Barbon, A., Barlati, S. Cytogenet. Cell Genet. (2000)
- Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR 5/6/7 in the human epileptogenic neocortex. DeFelipe, J., Huntley, G.W., del Río, M.R., Sola, R.G., Morrison, J.H. Brain Res. (1994)
- Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal. Ren, Z., Riley, N.J., Needleman, L.A., Sanders, J.M., Swanson, G.T., Marshall, J. J. Biol. Chem. (2003)
- Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Porter, R.H., Eastwood, S.L., Harrison, P.J. Brain Res. (1997)
- RNA editing at the Q/R site for the glutamate receptor subunits GLUR2, GLUR5, and GLUR6 in hippocampus and temporal cortex from epileptic patients. Kortenbruck, G., Berger, E., Speckmann, E.J., Musshoff, U. Neurobiol. Dis. (2001)
- RNA editing of human kainate receptor subunits. Nutt, S.L., Kamboj, R.K. Neuroreport (1994)
- Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons. Lai, F., Chen, C.X., Lee, V.M., Nishikura, K. J. Neurochem. (1997)
- Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. Jane, D.E., Hoo, K., Kamboj, R., Deverill, M., Bleakman, D., Mandelzys, A. J. Med. Chem. (1997)
- Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Kayadjanian, N., Lee, H.S., Piña-Crespo, J., Heinemann, S.F. Mol. Cell. Neurosci. (2007)
- Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey. Vickers, J.C., Huntley, G.W., Edwards, A.M., Moran, T., Rogers, S.W., Heinemann, S.F., Morrison, J.H. J. Neurosci. (1993)
- Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Swanson, G.T., Green, T., Heinemann, S.F. Mol. Pharmacol. (1998)
- Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. Dominguez, E., Iyengar, S., Shannon, H.E., Bleakman, D., Alt, A., Arnold, B.M., Bell, M.G., Bleisch, T.J., Buckmaster, J.L., Castano, A.M., Del Prado, M., Escribano, A., Filla, S.A., Ho, K.H., Hudziak, K.J., Jones, C.K., Martinez-Perez, J.A., Mateo, A., Mathes, B.M., Mattiuz, E.L., Ogden, A.M., Simmons, R.M., Stack, D.R., Stratford, R.E., Winter, M.A., Wu, Z., Ornstein, P.L. J. Med. Chem. (2005)
- Single cell RT-PCR proceeds without the risk of genomic DNA amplification. Johansen, F.F., Lambolez, B., Audinat, E., Bochet, P., Rossier, J. Neurochem. Int. (1995)
- Non-plaque dystrophic dendrites in Alzheimer hippocampus: a new pathological structure revealed by glutamate receptor immunocytochemistry. Aronica, E., Dickson, D.W., Kress, Y., Morrison, J.H., Zukin, R.S. Neuroscience (1998)
- Glutamate receptor 5/6/7-like and glutamate transporter-1-like immunoreactivity in the leech central nervous system. Thorogood, M.S., Almeida, V.W., Brodfuehrer, P.D. J. Comp. Neurol. (1999)
- The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates. Palecek, J., Neugebauer, V., Carlton, S.M., Iyengar, S., Willis, W.D. Pain (2004)