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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes.

CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a subpopulation of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.[1]

References

  1. The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. Virtaneva, K.I., Angelisová, P., Baumruker, T., Horejsí, V., Nevanlinna, H., Schröder, J. Immunogenetics (1993) [Pubmed]
 
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