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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes.

We investigated whether astrocytes store and synthesize agmatine (decarboxylated arginine), an endogenous ligand for imidazoline and alpha 2-adrenergic receptors, in brain. Agmatine, detected chemically and immunocytochemically, is contained in cultured astrocytes and C6 glioma cells (8.5 +/- 1.4 and 1.8 +/- 0.6 nmol mg-1 protein, respectively). Glial membranes express activity for arginine decarboxylase (ADC), the biosynthetic enzyme for agmatine (astrocytes 85.4 +/- 9.2; C6 cells 18.2 +/- 3.12 nmol h-1 mg-1 protein). Lipopolysaccharide, and inducer of glial nitric oxide synthase (iNOS), significantly reduced (C6) or did not affect (astrocytes) ADC activity. Inferferon-gamma, not affecting iNOS, elevated ADC activity in both cell types. Astrocytes are a site of synthesis and storage of agmatine. ADC and iNOS enzymes synthesizing distinct bioactive products from L-arginine, may be reciprocally regulated.[1]

References

  1. Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes. Regunathan, S., Feinstein, D.L., Raasch, W., Reis, D.J. Neuroreport (1995) [Pubmed]
 
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