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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity.

We analyzed the expression and function of the co-stimulatory molecules B7-1 (CD80) and B7-2 (CD86) during contact sensitivity reactions induced by the hapten 2,4-dinitrofluorobenzene (DNFB). In the normal skin, only a few epidermal Langerhans cells or dermal dendritic cells express B7-2. In contrast, following challenge with DNFB, expression of B7-2 is up-regulated in both epidermis and dermis. Importantly, B7-1 is induced later and at lower levels compared to B7-2. Intravenous injections of anti-B7-2 mAb, but not anti-B7-1 mAb partially inhibit the hapten-induced contact sensitivity reaction. Experiments in which mice are injected differentially with anti-B7-2 mAb, either before the afferent or before the efferent phase of the contact sensitivity response, suggest that B7-2 is important for successful antigen priming.[1]


  1. Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Reiser, H., Schneeberger, E.E. Eur. J. Immunol. (1996) [Pubmed]
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