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Chemical Compound Review

DNFB     1-fluoro-2,4-dinitro-benzene

Synonyms: DNPF, FDNB, PubChem4416, CHEMBL167423, CPD-8983, ...
 
 
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Disease relevance of Fluorodinitrobenzene

 

High impact information on Fluorodinitrobenzene

 

Chemical compound and disease context of Fluorodinitrobenzene

 

Biological context of Fluorodinitrobenzene

 

Anatomical context of Fluorodinitrobenzene

 

Associations of Fluorodinitrobenzene with other chemical compounds

 

Gene context of Fluorodinitrobenzene

  • To determine whether UVB can induce suppression in TNF-R1(-) mice, mice were irradiated on the shaved abdomen with 96 mj/cm2 UVB and 3 days later they were painted with 0.5% DNFB (sensitization dose), followed 5 days later with 0.2% DNFB to the left ear (challenge dose) [30].
  • Significant increases in IL-2 mRNA were detected in the skin after dinitrofluorobenzene challenge in normal mice, while this response was blunted in CD28 -/- mice [31].
  • Generation of contact hypersensitivity to dinitrofluorobenzene, which involves Th1 and CD8(+) effector cells, was also intact in IL-13(-/-) mice [32].
  • In contrast, following challenge with DNFB, expression of B7-2 is up-regulated in both epidermis and dermis [33].
  • Local injection of IL-1ra to sensitized BALB/c mice just before challenge with dinitrofluorobenzene resulted in a significant reduction in the intensity of CHS responses, assessed by ear swelling [34].
 

Analytical, diagnostic and therapeutic context of Fluorodinitrobenzene

References

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  2. The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues. Janeway, C.A., Cohen, B.E., Ben-Sasson, S.Z., Paul, W.E. J. Exp. Med. (1975) [Pubmed]
  3. Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani, M., Billings, S.D., Perkins, S.M., Howard, K.M., Ishii, S., Shimizu, T., Travers, J.B. J. Clin. Invest. (2005) [Pubmed]
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  5. Immune electron microscopic localization of dinitrophenyl-modified ribosomal protein S19 in reconstituted Escherichia coli 30 S subunits using antibodies to dinitrophenol. Olson, H.M., Olah, T.V., Cooperman, B.S., Glitz, D.G. J. Biol. Chem. (1988) [Pubmed]
  6. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity. Kehren, J., Desvignes, C., Krasteva, M., Ducluzeau, M.T., Assossou, O., Horand, F., Hahne, M., Kägi, D., Kaiserlian, D., Nicolas, J.F. J. Exp. Med. (1999) [Pubmed]
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  10. Antigen receptors on murine T lymphocytes in contact sensitivity. III. Mechanism of negative feedback regulation by auto-anti-idiotypic antibody. Moorhead, J.W. J. Exp. Med. (1982) [Pubmed]
  11. Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor. Moorhead, J.W. J. Exp. Med. (1979) [Pubmed]
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  14. Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reaction. Rijnierse, A., Koster, A.S., Nijkamp, F.P., Kraneveld, A.D. J. Immunol. (2006) [Pubmed]
  15. IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo. Müller, G., Saloga, J., Germann, T., Schuler, G., Knop, J., Enk, A.H. J. Immunol. (1995) [Pubmed]
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  18. Modulation of the population density of identifiable epidermal Langerhans cells associated with enhancement or suppression of cutaneous immune reactivity. Rheins, L.A., Nordlund, J.J. J. Immunol. (1986) [Pubmed]
  19. A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells. Lee, T.C., Uemura, Y., Snyder, F. J. Biol. Chem. (1992) [Pubmed]
  20. Desensitization of contact allergy to DNFB in mice. I. Description of a model system. Claman, H.N., Jaffee, B.D. J. Immunol. (1983) [Pubmed]
  21. Genetic restrictions for the induction of suppressor T cells by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitivity. Role of the H-2D region of the major histocompatibility complex. Miller, S.D., Sy, M.S., Claman, H.N. J. Exp. Med. (1978) [Pubmed]
  22. H-2 restriction of suppressor T-cell induction by hapten-modified lymphoid cells in tolerance to 1-fluoro-2,4-dinitrobenzene contact sensitization. Miller, S.D., Sy, M.S., Claman, H.N. J. Exp. Med. (1977) [Pubmed]
  23. Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. Howard, J.G., Hale, C., Liew, F.Y. J. Exp. Med. (1980) [Pubmed]
  24. Active suppression of 1-fluoro-2,4-dinitrobenzene-immune T cells. Requirement of an auxiliary T cell induced by antigen. Sy, M.S., Miller, S.D., Moorhead, J.W., Claman, H.N. J. Exp. Med. (1979) [Pubmed]
  25. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells. Xu, H., DiIulio, N.A., Fairchild, R.L. J. Exp. Med. (1996) [Pubmed]
  26. Ribonucleolytic activity of angiogenin: essential histidine, lysine, and arginine residues. Shapiro, R., Weremowicz, S., Riordan, J.F., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  27. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Wang, M., Qin, X., Mudgett, J.S., Ferguson, T.A., Senior, R.M., Welgus, H.G. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  28. Tolerance and contact sensitivity to DNFB in mice. V. Induction of tolerance with DNP compounds and with free and membrane-associated DNFB. Claman, H.N. J. Immunol. (1976) [Pubmed]
  29. Suppressor cells for the afferent phase of contact sensitivity to picryl chloride: inhibition of DNA synthesis induced by T cells from mice injected with picryl sulfonic acid. Thomas, W.R., Watkins, M.C., Asherson, G.L. J. Immunol. (1979) [Pubmed]
  30. Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression. Kondo, S., Wang, B., Fujisawa, H., Shivji, G.M., Echtenacher, B., Mak, T.W., Sauder, D.N. J. Immunol. (1995) [Pubmed]
  31. Contribution of the CD28 molecule to allergic and irritant-induced skin reactions in CD28 -/- mice. Kondo, S., Kooshesh, F., Wang, B., Fujisawa, H., Sauder, D.N. J. Immunol. (1996) [Pubmed]
  32. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. Herrick, C.A., Xu, L., McKenzie, A.N., Tigelaar, R.E., Bottomly, K. J. Immunol. (2003) [Pubmed]
  33. Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Reiser, H., Schneeberger, E.E. Eur. J. Immunol. (1996) [Pubmed]
  34. Interleukin-1 receptor antagonist suppresses contact hypersensitivity. Kondo, S., Pastore, S., Fujisawa, H., Shivji, G.M., McKenzie, R.C., Dinarello, C.A., Sauder, D.N. J. Invest. Dermatol. (1995) [Pubmed]
  35. Immunological suppression in mice treated with hematoporphyrin derivative photoradiation. Elmets, C.A., Bowen, K.D. Cancer Res. (1986) [Pubmed]
  36. Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines. Ali-Osman, F., Stein, D.E., Renwick, A. Cancer Res. (1990) [Pubmed]
  37. Phosphatidylserine enhances the ability of epidermal Langerhans cells to induce contact hypersensitivity. Girolomoni, G., Pastore, S., Zacchi, V., Cavani, A., Marconi, A., Giannetti, A. J. Immunol. (1993) [Pubmed]
  38. Regulation of contact sensitivity to DNFB in the mouse: effects of adult thymectomy and thymic factor. Erard, D., Charreire, J., Auffredou, M.T., Galanaud, P., Bach, J.F. J. Immunol. (1979) [Pubmed]
 
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