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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows.

OBJECTIVE--To compare relative efficacy of dexamethasone and flumethasone alone or in combination with rapid IV infusion of glucose for treatment of ketosis in cattle. DESIGN--Clinical trial. ANIMALS--127 cows with urine acetoacetate concentration > or = 60 mg/dl. PROCEDURE--Cows were treated with 500 ml of 50% glucose solution. IV, and 40 mg of dexamethasone, IM (group 1), 40 mg of dexamethasone, IM (group 2), 5 mg of flumethasone (group 3), or 500 ml of 50% glucose solution, IV, and 5 mg of flumethasone (group 4). Treatment success was defined as recovery after a single treatment without relapse during the same lactation. Uterine disease (retained placenta or metritis), parity, and pretreatment plasma glucose, serum beta-hydroxybutyric acid, and urine acetoacetate concentrations were evaluated as possible confounding factors affecting recovery. RESULTS--Only uterine disease was found to have a significant effect on recovery. Treatments 1 and 4 were significantly more efficacious than was treatment 2, but efficacy of treatment 2 was not significantly different from that of treatment 3. Regardless of treatment, cows with uterine disease were less likely to have a successful outcome than were cows without uterine disease. In all treatment groups, plasma glucose concentration increased and serum beta-hydroxybutyric acid and urine acetoacetate concentrations decreased following treatment. CLINICAL IMPLICATIONS--In this study, treatment of ketosis in dairy cattle with a corticosteriod alone was less efficacious than treatment with glucose and a corticosteroid.[1]


  1. Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows. Shpigel, N.Y., Chen, R., Avidar, Y., Bogin, E. J. Am. Vet. Med. Assoc. (1996) [Pubmed]
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