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Chemical Compound Review

NSC-54702     6,9-difluoro-11,17-dihydroxy- 17-(2...

Synonyms: AC1L1FSK, AC1Q5HJX, NSC54702, AR-1H0510, FT-0626440, ...
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Disease relevance of flumethasone


High impact information on flumethasone


Chemical compound and disease context of flumethasone


Biological context of flumethasone

  • Twenty-five dairy cows were assigned randomly by breed to flumethasone treatment (10 mug/day, 13 cows) or placebo control (12 cows) from 4 to 44 wk of lactation [12].
  • With 24 Holstein cows in a randomized block design, daily Flumethasone administration was initiated 4 days postpartum and continued until milk secretion ceased or the completion of 305 days on treatment [5].
  • Experiment 2 was conducted to determine if a lower dosage of clenbuterol, given as a single injection 37 h after flumethasone, would delay lambing without increasing the proportion of stillbirths [13].
  • Experiment 2 was conducted to determine whether FM given to Adx gilts immediately after surgery could have inhibited estrus and ovulation [14].
  • In vitro investigations on the use of anti-inflammatory agents demonstrated that methylprednisolone had a stabilizing effect on leukocytes by maintaining viability and reducing degranulation, whereas flumethasone was detrimental to cell viability [15].

Anatomical context of flumethasone


Associations of flumethasone with other chemical compounds

  • In the first experiment, four groups of cows and heifers were used: untreated (C, n=9), 10 mg flumethasone on day 281 of gestation (F, n=9), 100 mg progesterone daily from days 276 through 283 and 50 mg progesterone on day 284 (P, n=6), and (P + F on day 284, n=7) [17].
  • We compared the inhibition rate in both age groups and could demonstrate that Dex, Flu, and Flxin each at the highest dose, and PB at all doses used, inhibited PAF-induced aggregation less (P less than 0.05) in N-PMNs than in A-PMNs [18].

Analytical, diagnostic and therapeutic context of flumethasone


  1. Comparative evaluation of skin atrophy in man induced by topical corticoids. Jablonska, S., Groniowska, M., Dabroswki, J. Br. J. Dermatol. (1979) [Pubmed]
  2. Prophylaxis of respiratory distress syndrome in premature calves by administration of dexamethasone or a prostaglandin F2 alpha analogue to their dams before parturition. Zaremba, W., Grunert, E., Aurich, J.E. Am. J. Vet. Res. (1997) [Pubmed]
  3. Flumethasone pivalate (Locorten) in the treatment of oral diseases. Scaglione, F., Falchi, M., Bichisao, E., Fraschini, F. Drugs under experimental and clinical research. (1985) [Pubmed]
  4. Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia. Bednarek, D., Zdzisińska, B., Kondracki, M., Kandefer-Szerszeń, M. Vet. Microbiol. (2003) [Pubmed]
  5. Lactational response of dairy cows to oral administration of a synthetic glucocorticoid. Swanson, L.V., Lind, R.E. J. Dairy Sci. (1976) [Pubmed]
  6. Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis. Janszen, B.P., Knijn, H., Van der Weyden, G.C., Bevers, M.M., Dieleman, S.J., Taverne, M.A. Biol. Reprod. (1990) [Pubmed]
  7. Immunoaffinity chromatography combined on-line with high-performance liquid chromatography-mass spectrometry for the determination of corticosteroids. Creaser, C.S., Feely, S.J., Houghton, E., Seymour, M. Journal of chromatography. A. (1998) [Pubmed]
  8. Stimulation of androgen and oestrogen concentrations in plasma of cows after administration of a synthetic glucocorticoid (flumethasone) at the end of gestation. Möstl, E., Choi, H.S., Bamberg, E. J. Endocrinol. (1985) [Pubmed]
  9. Immunochemical screening and liquid chromatographic-tandem mass spectrometric confirmation of drug residues in edible tissues of calves injected with a therapeutic dose of the synthetic glucocorticoids dexamethasone and flumethasone. Van Den Hauwe, O., Schneider, M., Sahin, A., Van Peteghem, C.H., Naegeli, H. J. Agric. Food Chem. (2003) [Pubmed]
  10. Studies on Sudanese medicinal plants. II. Evaluation of an extract of Lupinus termis seeds in chronic eczema. Antoun, M.D., Taha, O.M. J. Nat. Prod. (1981) [Pubmed]
  11. An evaluation of betamethasone dipropionate (Diprosone) versus Locacorten 0.02% cream. Mali, J.W. Dermatologica (1976) [Pubmed]
  12. Effect of a synthetic corticoid on milk yield and composition and on blood metabolites and hormones in dairy cows. Head, H.H., Thatcher, W.W., Wilcox, C.J., Bachman, K.C. J. Dairy Sci. (1976) [Pubmed]
  13. The effect of clenbuterol on time of lambing and neonatal death loss. Kiesling, D.O., Meredith, S., Warren, J.E. Theriogenology (1988) [Pubmed]
  14. Effects of adrenalectomy and glucocorticoids on puberty in gilts reared in confinement. Killian, D.B., Kiesling, D.O., Wulff, F.P., Stewart, A.N. J. Anim. Sci. (1987) [Pubmed]
  15. Mammary leukocyte response to drug therapy. Nickerson, S.C., Paape, M.J., Harmon, R.J., Ziv, G. J. Dairy Sci. (1986) [Pubmed]
  16. Dehydroepiandrosterone and epitestosterone in the blood of cows at term. Möstl, E., Janowski, T., Palme, R., Rás, A., Zduńczyk, S., Bamberg, E. Zentralblatt für Veterinärmedizin. Reihe A. (1989) [Pubmed]
  17. Synchronization of parturition in beef cattle using delay as well as induction. Ottobre, J.S., Inskeep, E.K. Theriogenology (1983) [Pubmed]
  18. In vitro aggregation of bovine neonatal neutrophils. A comparative study with adult cattle. Zwahlen, R.D., Roth, D.R., Wyder-Walther, M. Inflammation (1990) [Pubmed]
  19. Analysis of flumethasone pivalate formulations by high-performance liquid chromatography. Lodge, B.A., Vincent, A. J. Chromatogr. (1984) [Pubmed]
  20. Generic immunoassay of corticosteroids with minimum pre-treatment of urine samples. Rodriguez, M.L., McConnell, I., Lamont, J., Campbell, J., FitzGerald, S.P. The Analyst. (1994) [Pubmed]
  21. The administration of flumethasone, by three different routes, its measurement in the plasma and some effects on wool growth in Merino wethers. Panaretto, B.A., Wallace, A.L. Aust. J. Biol. Sci. (1978) [Pubmed]
  22. Flumethasone-induced insulin resistance in calves. Sternbauer, K., Luthman, J., Jacobsson, S.O. Zentralblatt für Veterinärmedizin. Reihe A. (1998) [Pubmed]
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