Disease relevance of flumethasone

• Flumethasone pivalate can therefore be reckoned as a suitable topical corticosteroid especially for the long-term treatment of corticoid-responsive dermatoses [1].
• In calves delivered after flumethasone or dinoprost treatments, the degree of acidosis was significantly (P < 0.05) less than that in controls [2].
• The combination flumethasone pivalate + iodochlorohydroxychinoline drops was used in 40 patients, 24 males and 16 females, mean age 42.6 years, suffering from infectious enanthema (35%), periodontitis (30%), aphthous stomatitis (25%) and abscess due to prosthesis (10%) [3].
• In the blood of the calves which received oxytetracycline and flumethasone (Group II), leukocytosis, neutrophilia and monocytosis with concomitant lymphopenia and a low number of T cells (CD2+) was observed [4].
• Effects of oral administration of 0, 5, 10, or 20 mug of 6 alpha, 9 alpha-difluoro-16alpha-methyl-prednisolone (Flumethasone) daily on milk and milk component yields, udder health reproductive performance, and body weight change were measured [5].

High impact information on flumethasone

• Calving was induced by a single i.m. injection of 5 mg flumethason on Day 270 of gestation [6].
• Flumethason-induced calving is preceded by a period of myometrial inhibition during luteolysis [6].
• On-line coupled immunoaffinity chromatography-reversed-phase high-performance liquid chromatography (IAC-HPLC) with detection by quadrupole ion trap mass spectrometry using a particle beam interface has been developed for the determination of the steroids, dexamethasone and flumethasone [7].
• Administration of flumethasone (3.5 mg i.m.) to six cows on day 260 of pregnancy induced parturition in only one animal [8].
• A field study was performed to assess the drug residue level in edible tissues after a therapeutic application of the synthetic glucocorticoids dexamethasone and flumethasone [9].

Chemical compound and disease context of flumethasone

• A double-blind clinical trial comparing a 10% ointment prepared from a 95% ethanol extract of Lupinus termis seeds with a 0.02% flumethasone pivalate ointment and a placebo showed that the Lupinus termis extractive was effective in the treatment of chronic eczema [10].
• A double-blind randomized evaluation of betamethasone dipropionate cream (Diprosone) compared with Locacorten 0.02% cream flumethason privalate in 60 patients over 3 consecutive weeks showed the betamethasone dipropionate cream to be significantly more effective in the treatment of psoriasis and other steroid-responsive dermatoses [11].

Biological context of flumethasone

• Twenty-five dairy cows were assigned randomly by breed to flumethasone treatment (10 mug/day, 13 cows) or placebo control (12 cows) from 4 to 44 wk of lactation [12].
• With 24 Holstein cows in a randomized block design, daily Flumethasone administration was initiated 4 days postpartum and continued until milk secretion ceased or the completion of 305 days on treatment [5].
• Experiment 2 was conducted to determine if a lower dosage of clenbuterol, given as a single injection 37 h after flumethasone, would delay lambing without increasing the proportion of stillbirths [13].
• Experiment 2 was conducted to determine whether FM given to Adx gilts immediately after surgery could have inhibited estrus and ovulation [14].
• In vitro investigations on the use of anti-inflammatory agents demonstrated that methylprednisolone had a stabilizing effect on leukocytes by maintaining viability and reducing degranulation, whereas flumethasone was detrimental to cell viability [15].

Anatomical context of flumethasone

• OBJECTIVE: To investigate effects of preterm induction of calving by administration of flumethasone and dinoprost on the lecithin-to-sphingomyelin ratio in amniotic fluid and on neonatal respiratory distress after birth [2].
• From Day 268 of gestation till two days after parturition blood samples were collected from the jugular vein of 5 cows with normal and 4 cows with flumethasone induced parturition and centrifuged immediately after sampling [16].

Associations of flumethasone with other chemical compounds

• In the first experiment, four groups of cows and heifers were used: untreated (C, n=9), 10 mg flumethasone on day 281 of gestation (F, n=9), 100 mg progesterone daily from days 276 through 283 and 50 mg progesterone on day 284 (P, n=6), and (P + F on day 284, n=7) [17].
• We compared the inhibition rate in both age groups and could demonstrate that Dex, Flu, and Flxin each at the highest dose, and PB at all doses used, inhibited PAF-induced aggregation less (P less than 0.05) in N-PMNs than in A-PMNs [18].

Analytical, diagnostic and therapeutic context of flumethasone

• Analysis of flumethasone pivalate formulations by high-performance liquid chromatography [19].
• A generic, rapid and sensitive enzyme linked immunosorbent assay (ELISA) test has been developed which allows large-scale simultaneous testing of synthetic corticosteroids viz., flumethasone, dexamethasone and betamethasone [20].
• In experiments 1 and 2 intravenous infusion of 1.20-1.33 mg flumethasone/kg(0.75) caused the shedding of all wool fibres about 30 days after treatment [21].
• Estimates of the metabolic clearance rates for flumethasone in experiments 1, 2 and 5 were 200-700 ml/min during the equilibrium concentration periods [21].
• Hyperinsulinemic, euglycemic clamp tests were performed before and after flumethasone treatment [22].

References