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Sayers, T.J. et al.

Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3.

Cytotoxic lymphocytes possess a number of serine proteases (granzymes) usually localized in cytoplasmic granules. To date, the DNA sequences of four human granzymes have been reported. A fifth human granzyme (granzyme 3) has been biochemically purified and its N-terminal amino acid sequence has been reported. This enzyme was described as possessing tryptase activity, cleaving synthetic substrates after arginine or lysine. We recently cloned a rat granzyme tryptase (RNK-Tryp-2), and used this cDNA to screen human cDNA libraries. Isolation of cDNA fragments of a human gene could be overlapped to provide a complete cDNA sequence, which we designated HNK-Tryp-2. The N-terminal amino acid sequence deduced from HNK-Tryp-2 was identical to that reported for granzyme 3. This gene appears to be a single copy gene that is expressed in isolated natural killer cells and T cells as well as in tissues containing these cells.[1]

References

Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. Sayers, T.J., Lloyd, A.R., McVicar, D.W., O'Connor, M.D., Kelly, J.M., Carter, C.R., Wiltrout, T.A., Wiltrout, R.H., Smyth, M.J. J. Leukoc. Biol. (1996) [Pubmed]

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