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Gene Review

GZMK  -  granzyme K (granzyme 3; tryptase II)

Homo sapiens

Synonyms: Fragmentin-3, Granzyme K, Granzyme-3, NK-Tryp-2, NK-tryptase-2, ...
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Disease relevance of GZMK


High impact information on GZMK


Biological context of GZMK


Anatomical context of GZMK


Associations of GZMK with chemical compounds

  • Granzyme 3 has the expected features of the chymotrypsin family of serine proteases, and is closely related to other human granzymes (40-45% identity) [4].


  1. Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity. Hirata, Y., Inagaki, H., Shimizu, T., Li, Q., Nagahara, N., Minami, M., Kawada, T. Arch. Biochem. Biophys. (2006) [Pubmed]
  2. Activation of an interleukin 1 converting enzyme-dependent apoptosis pathway by granzyme B. Shi, L., Chen, G., MacDonald, G., Bergeron, L., Li, H., Miura, M., Rotello, R.J., Miller, D.K., Li, P., Seshadri, T., Yuan, J., Greenberg, A.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. Sayers, T.J., Lloyd, A.R., McVicar, D.W., O'Connor, M.D., Kelly, J.M., Carter, C.R., Wiltrout, T.A., Wiltrout, R.H., Smyth, M.J. J. Leukoc. Biol. (1996) [Pubmed]
  4. Cloning of cDNA for human granzyme 3. Przetak, M.M., Yoast, S., Schmidt, B.F. FEBS Lett. (1995) [Pubmed]
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