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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells.

The APC gene is mutated in familial adenomatous polyposis and sporadic colorectal tumors. The product of this gene is a 300 kDa cytoplasmic protein associated with catenin. In the present study, we examined the subcellular localization of the APC protein and beta-catenin in the mouse colon by double-labeling immunocytochemistry. While the APC protein was localized in the lateral and apical cytoplasm and in microvilli of the epithelial cells, beta-catenin was present exclusively in the lateral cytoplasm. Double-labeling-immunoelectron microscopy demonstrated precise colocalization of the APC protein and beta-catenin along the lateral plasma membrane. These results suggest that the APC protein functions in cooperation with beta-catenin in the lateral cytoplasm but has other functions independent of beta-catenin in the apical cytoplasm and in microvilli.[1]


  1. The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. Senda, T., Miyashiro, I., Matsumine, A., Baeg, G.H., Monden, T., Kobayashil, S., Monden, M., Toyoshima, K., Akiyama, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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