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MeSH Review

Genes, APC

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Disease relevance of Genes, APC


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Biological context of Genes, APC


Anatomical context of Genes, APC


Associations of Genes, APC with chemical compounds


Gene context of Genes, APC


Analytical, diagnostic and therapeutic context of Genes, APC


  1. The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. Giardiello, F.M., Brensinger, J.D., Petersen, G.M., Luce, M.C., Hylind, L.M., Bacon, J.A., Booker, S.V., Parker, R.D., Hamilton, S.R. N. Engl. J. Med. (1997) [Pubmed]
  2. Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Spirio, L.N., Samowitz, W., Robertson, J., Robertson, M., Burt, R.W., Leppert, M., White, R. Nat. Genet. (1998) [Pubmed]
  3. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., Polakis, P. Science (1996) [Pubmed]
  4. The clinical correlates of a 3' truncating mutation (codons 1982-1983) in the adenomatous polyposis coli gene. Gardner, R.J., Kool, D., Edkins, E., Walpole, I.R., Macrae, F.A., Nasioulas, S., Scott, W.J. Gastroenterology (1997) [Pubmed]
  5. Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Kucherlapati, M., Yang, K., Kuraguchi, M., Zhao, J., Lia, M., Heyer, J., Kane, M.F., Fan, K., Russell, R., Brown, A.M., Kneitz, B., Edelmann, W., Kolodner, R.D., Lipkin, M., Kucherlapati, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Kielman, M.F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M.M., Roberts, S., Smits, R., Fodde, R. Nat. Genet. (2002) [Pubmed]
  7. Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis. Goode, S., Perrimon, N. Genes Dev. (1997) [Pubmed]
  8. Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. Bala, S., Wünsch, P.H., Ballhausen, W.G. Gastroenterology (1997) [Pubmed]
  9. Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine. Rashid, A., Hamilton, S.R. Gastroenterology (1997) [Pubmed]
  10. Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. Nakatsuru, S., Yanagisawa, A., Ichii, S., Tahara, E., Kato, Y., Nakamura, Y., Horii, A. Hum. Mol. Genet. (1992) [Pubmed]
  11. The I1307K polymorphism of the APC gene in colorectal cancer. Prior, T.W., Chadwick, R.B., Papp, A.C., Arcot, A.N., Isa, A.M., Pearl, D.K., Stemmermann, G., Percesepe, A., Loukola, A., Aaltonen, L.A., De La Chapelle, A. Gastroenterology (1999) [Pubmed]
  12. Dinucleotide repeat polymorphism at the D5S134 locus linked to the adenomatous polyposis coli (APC) gene. Koorey, D.J., McCaughan, G.W., Trent, R.J., Gallagher, N.D. Hum. Mol. Genet. (1992) [Pubmed]
  13. The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene contains human colon tumor mutational hotspots. Muniappan, B.P., Thilly, W.G. Cancer Res. (2002) [Pubmed]
  14. Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis. Chiu, C.H., McEntee, M.F., Whelan, J. Cancer Res. (1997) [Pubmed]
  15. Detection of protein truncating mutations in exons 1-14 of the APC gene using an in vivo fusion protein assay. Mutations in brief no. 214. Online. Andreutti-Zaugg, C., Couturier, A., Chappuis, P., Hutter, P. Hum. Mutat. (1999) [Pubmed]
  16. Apc deficiency predisposes to renal carcinoma in the mouse. Sansom, O.J., Griffiths, D.F., Reed, K.R., Winton, D.J., Clarke, A.R. Oncogene (2005) [Pubmed]
  17. Thyroid carcinoma usually occurs in patients with familial adenomatous polyposis in the absence of biallelic inactivation of the adenomatous polyposis coli gene. Cetta, F., Curia, M.C., Montalto, G., Gori, M., Cama, A., Battista, P., Barbarisi, A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  18. Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in Apc delta 716 knockout mice. Oshima, M., Oshima, H., Tsutsumi, M., Nishimura, S., Sugimura, T., Nagao, M., Taketo, M.M. Mol. Carcinog. (1996) [Pubmed]
  19. Roles of COX-1 and COX-2 in gastrointestinal pathophysiology. Sakamoto, C. J. Gastroenterol. (1998) [Pubmed]
  20. Initiation of colorectal cancer: where do the two hits hit? Komarova, N.L., Wang, L. Cell Cycle (2004) [Pubmed]
  21. Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice. Moser, A.R., Hegge, L.F., Cardiff, R.D. Cancer Res. (2001) [Pubmed]
  22. Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine requires p53. Narayan, S., Jaiswal, A.S. J. Biol. Chem. (1997) [Pubmed]
  23. A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast. Harkness, T.A., Shea, K.A., Legrand, C., Brahmania, M., Davies, G.F. Genetics (2004) [Pubmed]
  24. Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals. Nagao, M., Wakabayashi, K., Ushijima, T., Toyota, M., Totsuka, Y., Sugimura, T. Environ. Health Perspect. (1996) [Pubmed]
  25. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Perreault, N., Sackett, S.D., Katz, J.P., Furth, E.E., Kaestner, K.H. Genes Dev. (2005) [Pubmed]
  26. Loss of beta-catenin expression in metastatic gastric cancer. Ebert, M.P., Yu, J., Hoffmann, J., Rocco, A., Röcken, C., Kahmann, S., Müller, O., Korc, M., Sung, J.J., Malfertheiner, P. J. Clin. Oncol. (2003) [Pubmed]
  27. Cycling without the cyclosome: modeling a yeast strain lacking the APC. Thornton, B.R., Chen, K.C., Cross, F.R., Tyson, J.J., Toczyski, D.P. Cell Cycle (2004) [Pubmed]
  28. E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Smits, R., Ruiz, P., Diaz-Cano, S., Luz, A., Jagmohan-Changur, S., Breukel, C., Birchmeier, C., Birchmeier, W., Fodde, R. Gastroenterology (2000) [Pubmed]
  29. Genomic analysis of Barrett's esophagus after ablative therapy: persistence of genetic alterations at tumor suppressor loci. Hage, M., Siersema, P.D., Vissers, K.J., Dinjens, W.N., Steyerberg, E.W., Haringsma, J., Kuipers, E.J., van Dekken, H. Int. J. Cancer (2006) [Pubmed]
  30. Alternatively spliced adenomatous polyposis coli (APC) gene transcripts that delete exons mutated in attenuated APC. Samowitz, W.S., Thliveris, A., Spirio, L.N., White, R. Cancer Res. (1995) [Pubmed]
  31. Novel exon connections of the brain-specific (BS) exon of the adenomatous polyposis coli gene. Bardos, J., Sulekova, Z., Ballhausen, W.G. Int. J. Cancer (1997) [Pubmed]
  32. Detection of sequence variations in the adenomatous polyposis coli (APC) gene using denaturing high-performance liquid chromatography. Wu, G., Wu, W., Hegde, M., Fawkner, M., Chong, B., Love, D., Su, L.K., Lynch, P., Snow, K., Richards, C.S. Genet. Test. (2001) [Pubmed]
  33. Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. Chu, A.J., Chou, T.H., Chen, B.D. Front. Biosci. (2004) [Pubmed]
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