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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Dopamine and serotonin in the trout (Oncorhynchus mykiss) pituitary: main metabolites and changes during gonadal recrudescence.

Monoamine neurotransmitters and their metabolites in the trout pituitary have been studied. Dopamine (DA), serotonin (5HT), dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5HIAA) were separated as pure peaks by HPLC. Peak purity and identity were confirmed by electrochemical behavior. However, measurable amounts of the O-methylated DA metabolites 3-methoxytyramine and homovanillic acid were not detected in pituitary glands of different-aged trout or during the reproductive cycle. Treatment with L-DOPA or DA increased DOPAC levels, whereas O-methylated DA metabolites remained undetectable. Thus, MAO may be the major, if not the only, enzyme involved in DA catabolism in trout pituitary. A pronounced decline in dopaminergic turnover, measured as the DOPAC/DA ratio, was seen as gonadal recrudescence developed. 5HT or 5HIAA levels were not associated with reproductive status.[1]

References

  1. Dopamine and serotonin in the trout (Oncorhynchus mykiss) pituitary: main metabolites and changes during gonadal recrudescence. Hernandez-Rauda, R., Otero, J., Rey, P., Rozas, G., Aldegunde, M. Gen. Comp. Endocrinol. (1996) [Pubmed]
 
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