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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Systemic argyria secondary to topical silver nitrate.

A case of generalized argyria secondary to topical silver nitrate use on the oral mucosa is described, and the nature and history of argyria reviewed. The patient has extreme pigmentation of her skin and abdominal viscera, as seen on physical examination, gastroduodenoscopy, and laparotomy. Her use of silver nitrate applicators was uncontrolled by her dentist and pharmacist, and the diagnosis of argyria was not made until 2 1/2 years of heavy usage had passed. Avoidance of similar cases requires the careful scrutiny of silver-containing medicinal usage by all health practitioners and pharmacists. Although the systemic distribution of silver in both elemental and ionic forms can be linked with no systemic toxicity, the resultant pigmentation can be devastating to the patient.[1]


  1. Systemic argyria secondary to topical silver nitrate. Marshall, J.P., Schneider, R.P. Archives of dermatology. (1977) [Pubmed]
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