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Chemical Compound Review

CID4125394     silver nitrate

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Disease relevance of silver nitrate

  • As compared with historical controls, the incidence of gonococcal ophthalmia neonatorum decreased 83 percent among infants treated with silver nitrate and 93 percent among those treated with tetracycline [1].
  • Here we report that the active principle of AEF extracted from the spleen of mice with silver nitrate-induced AA amyloidosis was identified unequivocally as the AA fibril itself [2].
  • E. coli DNA, labeled in thymine, photosensitized by silver nitrate, and irradiated by 254 nm monochromatic light, was the substrate [3].
  • Using a one-step silver nitrate staining technique, routinely processed tumour tissues of 49 carcinomas of the colon were investigated to demonstrate silver-stained nucleoli (Ag-nus) and argyrophilic proteins associated with the so-called nucleolar organizer regions (Ag-NORs) [4].
  • In the mice subjected to corneal injury with silver nitrate and to intramuscular injection with either saline or a control adenovirus expressing beta-galactosidase (AdLacZ), corneal opacification composed of extracellular matrix (ECM) accumulation, of infiltration of neutrophils and monocytes/macrophages, and of angiogenesis were all induced [5].

Psychiatry related information on silver nitrate

  • This new method yields more consistent results in fungal staining without background staining, since the reaction time in the ammoniacal silver nitrate solution is prolonged [6].

High impact information on silver nitrate


Chemical compound and disease context of silver nitrate


Biological context of silver nitrate

  • In most instances, the blastomere-derived chromosomes did not display silver-nitrate-staining NOR [17].
  • In the majority of cases, when blastomere nuclei remained in interphase, the characteristic silver-nitrate-staining fine reticular material either was not seen, or the nuclear contents were dispersed into clumps of chromatin-like material [17].
  • This dithymidine phosphate analogue is comparatively resistant to hydrolysis by nuclease P1, but the P-S bond is readily cleaved by aqueous solutions of either iodine or silver nitrate [18].
  • Studies of the chemotactic function of control granulocytes after incubation with sera from burned patients yielded similar results; only the sera from patients treated with silver nitrate failed to suppress normal leukotaxis [19].
  • Treatment of this intermediate with silver nitrate accomplished the desired cyclization to the electron-rich pyrrole derivative 2 in moderate yield [20].

Anatomical context of silver nitrate


Associations of silver nitrate with other chemical compounds


Gene context of silver nitrate

  • Silver nitrate-stained gel electrophoresis demonstrated MMP and TIMP expression status [29].
  • Moreover, amyloid deposition in apoE-deficient mice as well as C57BL/6J control mice started 48 or 72 hours after injection of amyloid-enhancing factor and silver nitrate, although the amount of amyloid deposit in C57BL/6J control mice was slightly larger than that in apoE-deficient mice [30].
  • We monitored neuromuscular behavior, correlated with acetylcholinesterase and silver nitrate histochemistry at endplates, for changes in the timecourse of in vivo synapse elimination and assayed both thrombin activity and prothrombin expression in developing muscle [31].
  • We used the monoclonal antibodies PC-10, MIB-1, DO-1, 1B1O and EGFR 113 and the colloid silver nitrate (AgNOR) technique [32].
  • In experimental chronic inflammation, daily injection of silver nitrate (AgNO3) resulted in the deposition of 667 +/- 68 ng of amyloid A protein (AA)/mg of spleen after 25 days [33].

Analytical, diagnostic and therapeutic context of silver nitrate


  1. Prophylaxis of gonococcal and chlamydial ophthalmia neonatorum. A comparison of silver nitrate and tetracycline. Laga, M., Plummer, F.A., Piot, P., Datta, P., Namaara, W., Ndinya-Achola, J.O., Nzanze, H., Maitha, G., Ronald, A.R., Pamba, H.O. N. Engl. J. Med. (1988) [Pubmed]
  2. Transmissibility of systemic amyloidosis by a prion-like mechanism. Lundmark, K., Westermark, G.T., Nyström, S., Murphy, C.L., Solomon, A., Westermark, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Inhibition of enzymic incision of thymine dimers by covalently bound guanine adducts of 4-nitroquinoline-1-oxide in DNA. Duker, N.J., Merkel, G.W. Cancer Res. (1986) [Pubmed]
  4. Silver stained nucleolar organizer region proteins (Ag-NORs) as a predictor of prognosis in colonic cancer. Ofner, D., Tötsch, M., Sandbichler, P., Hallbrucker, C., Margreiter, R., Mikuz, G., Schmid, K.W. J. Pathol. (1990) [Pubmed]
  5. Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis. Sakamoto, T., Ueno, H., Sonoda, K., Hisatomi, T., Shimizu, K., Ohashi, H., Inomata, H. Gene Ther. (2000) [Pubmed]
  6. A simple and highly reproducible staining method for fungi and other polysaccharide-rich microorganisms in animal tissues. Tome, Y., Hayashi, I., Matsuoka, S., Yamamoto, M., Upton, M.P., Hirohashi, S., Shimosato, Y. Stain technology. (1988) [Pubmed]
  7. A controlled trial of povidone-iodine as prophylaxis against ophthalmia neonatorum. Isenberg, S.J., Apt, L., Wood, M. N. Engl. J. Med. (1995) [Pubmed]
  8. Pneumocystis carinii pneumonia. Diagnosis by examination of pulmonary secretions. Lau, W.K., Young, L.S., Remington, J.S. JAMA (1976) [Pubmed]
  9. Linkage of protection against amyloid fibril formation in the mouse to a single, autosomal dominant gene. Gonnerman, W.A., Elliott-Bryant, R., Carreras, I., Sipe, J.D., Cathcart, E.S. J. Exp. Med. (1995) [Pubmed]
  10. The ribosomal RNA gene cluster in aneuploid chickens: evidence for increased gene dosage and regulation of gene expression. Muscarella, D.E., Vogt, V.M., Bloom, S.E. J. Cell Biol. (1985) [Pubmed]
  11. Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis. Glawischnig, E., Hansen, B.G., Olsen, C.E., Halkier, B.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  12. Efficacy of neonatal ocular prophylaxis for the prevention of chlamydial and gonococcal conjunctivitis. Hammerschlag, M.R., Cummings, C., Roblin, P.M., Williams, T.H., Delke, I. N. Engl. J. Med. (1989) [Pubmed]
  13. Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins. Li, X.Z., Nikaido, H., Williams, K.E. J. Bacteriol. (1997) [Pubmed]
  14. Endometrial carcinoma with argyrophil cells: a histochemical and immunohistochemical analysis. Aguirre, P., Scully, R.E., Wolfe, H.J., DeLellis, R.A. Hum. Pathol. (1984) [Pubmed]
  15. An unusual complication of silver nitrate treatment of hemorrhagic cystitis: case report. Jerkins, G.R., Noe, H.N., Hill, D.E. J. Urol. (1986) [Pubmed]
  16. Antibacterial activity of Actisorb Plus, Actisorb and silver nitrate. Furr, J.R., Russell, A.D., Turner, T.D., Andrews, A. J. Hosp. Infect. (1994) [Pubmed]
  17. Cytogenetic study of silver-staining NOR in 8-cell-stage mouse blastomeres fused to 1-cell-stage embryos. Dyban, A.P., Lee, K., O'Neill, G.T., Speirs, S., Kaufman, M.H. Development (1988) [Pubmed]
  18. Synthesis and properties of dithymidine phosphate analogues containing 3'-thiothymidine. Cosstick, R., Vyle, J.S. Nucleic Acids Res. (1990) [Pubmed]
  19. Suppression of leukocyte chemotaxis in vitro by chemotherapeutic agents used in the management of thermal injuries. Warden, G.D., Mason, A.D., Pruitt, B.A. Ann. Surg. (1975) [Pubmed]
  20. A new color of the synthetic chameleon methoxyallene: synthesis of trifluoromethyl-substituted pyridinol derivatives: an unusual reaction mechanism, a remarkable crystal packing, and first palladium-catalyzed coupling reactions. Flögel, O., Dash, J., Brüdgam, I., Hartl, H., Reissig, H.U. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  21. An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. II. Studies on the effect of leukocytic elimination on corneal vascularization. Fromer, C.H., Klintworth, G.K. Am. J. Pathol. (1975) [Pubmed]
  22. Increased permeability of microcarrier-cultured endothelial monolayers in response to histamine and thrombin. A model for the in vitro study of increased vasopermeability. Killackey, J.J., Johnston, M.G., Movat, H.Z. Am. J. Pathol. (1986) [Pubmed]
  23. Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways. Baluk, P., Bolton, P., Hirata, A., Thurston, G., McDonald, D.M. Am. J. Pathol. (1998) [Pubmed]
  24. Ultrastructural observations on experimentally produced melanin pigmentation of the corneal epithelium. McCracken, J.S., Klintworth, G.K. Am. J. Pathol. (1976) [Pubmed]
  25. In vivo acylation of rat brain myelin proteolipid protein. Agrawal, H.C., Randle, C.L., Agrawal, D. J. Biol. Chem. (1982) [Pubmed]
  26. An immunologic assessment of brain-associated IgG in senile cerebral amyloidosis. Goust, J.M., Mangum, M., Powers, J.M. J. Neuropathol. Exp. Neurol. (1984) [Pubmed]
  27. Analysis of the genetic polymorphism of coagulation factor XIIIB (FXIIIB) by isoelectric focusing. Leifheit, H.J., Cleve, H. Electrophoresis (1988) [Pubmed]
  28. Pneumothorax in cystic fibrosis: management and outcome. McLaughlin, F.J., Matthews, W.J., Strieder, D.J., Khaw, K.T., Schuster, S., Shwachman, H. J. Pediatr. (1982) [Pubmed]
  29. Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas. Görögh, T., Beier, U.H., Bäumken, J., Meyer, J.E., Hoffmann, M., Gottschlich, S., Maune, S. Head & neck. (2006) [Pubmed]
  30. Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice. Hoshii, Y., Kawano, H., Cui, D., Takeda, T., Gondo, T., Takahashi, M., Kogishi, K., Higuchi, K., Ishihara, T. Am. J. Pathol. (1997) [Pubmed]
  31. A molecular mechanism for synapse elimination: novel inhibition of locally generated thrombin delays synapse loss in neonatal mouse muscle. Zoubine, M.N., Ma, J.Y., Smirnova, I.V., Citron, B.A., Festoff, B.W. Dev. Biol. (1996) [Pubmed]
  32. MDM2 and p53 expression in gliomas: a multivariate survival analysis including proliferation markers and epidermal growth factor receptor. Korkolopoulou, P., Christodoulou, P., Kouzelis, K., Hadjiyannakis, M., Priftis, A., Stamoulis, G., Seretis, A., Thomas-Tsagli, E. Br. J. Cancer (1997) [Pubmed]
  33. Effect of colchicine on experimental amyloidosis in two CBA/J mouse models. Chronic inflammatory stimulation and administration of amyloid-enhancing factor during acute inflammation. Brandwein, S.R., Sipe, J.D., Skinner, M., Cohen, A.S. Lab. Invest. (1985) [Pubmed]
  34. Genetic regulation of a structural polymorphism of human C3b receptor. Wong, W.W., Wilson, J.G., Fearon, D.T. J. Clin. Invest. (1983) [Pubmed]
  35. Endothelial cell heterogeneity in venules of mouse airways induced by polarized inflammatory stimulus. Murphy, T.J., Thurston, G., Ezaki, T., McDonald, D.M. Am. J. Pathol. (1999) [Pubmed]
  36. Seeding arterial prostheses with vascular endothelium. The nature of the lining. Herring, M.B., Dilley, R., Jersild, R.A., Boxer, L., Gardner, A., Glover, J. Ann. Surg. (1979) [Pubmed]
  37. Ultrastructural localization of nucleolar material by a simple silver staining technique devised for plant cells. Sato, S. J. Cell. Sci. (1985) [Pubmed]
  38. Fecal incontinence in children: treatment with percutaneous cecostomy tube placement--a prospective study. Chait, P.G., Shandling, B., Richards, H.M., Connolly, B.L. Radiology. (1997) [Pubmed]
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