Syntenic assignment of dopamine tautomerase (DCT) to bovine chromosome 12.
Heterologous primers were used to amplify an exon and intron-containing segment of the bovine homologue of the human dopachrome tautomerase gene. After confirmation of homology by sequence analysis (exon sequence similarity greater than 90%), bovine-specific primers were developed for synteny mapping purposes. The dopachrome tautomerase gene was assigned to bovine chromosome 12 (BTA12) with 97% concordance to the coagulation factor 10 locus. Together with previous synteny mapping of bovine chromosome 12 genes, fms-related tyrosine kinase, esterase D and 5-hydroxytryptamine receptor 2, this assignment further indicates conservation between human chromosome 13q and bovine chromosome 12.[1]References
- Syntenic assignment of dopamine tautomerase (DCT) to bovine chromosome 12. Sun, H.S., Womack, J.E., Kirkpatrick, B.W. Anim. Genet. (1996) [Pubmed]
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