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Gene Review

Esd  -  esterase D/formylglutathione hydrolase

Mus musculus

Synonyms: Es-10, Es10, Esterase 10, Esterase D, FGH, ...
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Disease relevance of Esd


High impact information on Esd

  • The order and orientation of gene segments within the Tar alpha-locus has also been established relative to the chromosome 14 marker, Es-10 [2].
  • The genes coding for adenosine kinase (ADK; ATP:adenosine 5'-phosphotransferase, EC and esterase-10 (ES-10; carboxylesterase, carboxylic-ester hydrolase, EC are both located on chromosome 14 in the mouse [3].
  • Recessive Adk- mutants of CAK have been isolated and analyzed for Es-10 phenotype and karyotypic abnormalities [3].
  • Using available DNA probes from human chromosome 13 we find that the loci for retinoblastoma, esterase D, p7D2, pG24E6.8 and pG14E1.9 lie distally to the 13q14 breakpoint, whereas those for p7F12, pHU10 and pG2E3.1 all lie proximally [4].
  • To determine the chromosome location of the largest unmapped linkage group in the rat (LG V containing multiple carboxylesterase loci), we used single-strand conformation polymorphism analysis to identify the rat esterase-10 gene in a panel of rat x mouse somatic cell hybrids [5].

Biological context of Esd


Anatomical context of Esd


Associations of Esd with chemical compounds


Other interactions of Esd


  1. Linkage studies of the esterase D and retinoblastoma genes to canine copper toxicosis: a model for Wilson disease. Yuzbasiyan-Gurkan, V., Wagnitz, S., Blanton, S.H., Brewer, G.J. Genomics (1993) [Pubmed]
  2. The cytotoxic T cell response to the male-specific histocompatibility antigen (H-Y) is controlled by two dominant immune response genes, one in the MHC, the other in the Tar alpha-locus. Epstein, R., Sham, G., Womack, J., Yagüe, J., Palmer, E., Cohn, M. J. Exp. Med. (1986) [Pubmed]
  3. Chromosome segregation is frequently associated with the expression of recessive mutations in mouse cells. Eves, E.M., Farber, R.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  4. Molecular definition in a somatic cell hybrid of a specific 2:13 translocation breakpoint in childhood rhabdomyosarcoma. Mitchell, C.D., Ventris, J.A., Warr, T.J., Cowell, J.K. Oncogene (1991) [Pubmed]
  5. Assignment of rat linkage group V to chromosome 19 by single-strand conformation polymorphism analysis of somatic cell hybrids. Pravenec, M., Simonet, L., Kren, V., St Lezin, E., Levan, G., Szpirer, J., Szpirer, C., Kurtz, T. Genomics (1992) [Pubmed]
  6. The murine retinoblastoma homolog maps to chromosome 14 near Es-10. Stone, J.C., Crosby, J.L., Kozak, C.A., Schievella, A.R., Bernards, R., Nadeau, J.H. Genomics (1989) [Pubmed]
  7. Genetics of formamidase-5 (brain formamidase) in the mouse: localization of the structural gene on chromosome 14. Cumming, R.B., Walton, M.F., Fuscoe, J.C., Taylor, B.A., Womack, J.E., Gaertner, F.H. Biochem. Genet. (1979) [Pubmed]
  8. Molecular evidence that the esterase-D gene lies proximal to the retinoblastoma susceptibility locus in chromosome region 13q14. Mitchell, C.D., Cowell, J.K. Hum. Genet. (1988) [Pubmed]
  9. Polymorphism of esterase-10 in Mus musculus. Peters, J., Nash, H.R. Biochem. Genet. (1976) [Pubmed]
  10. Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14. Lukey, T., Neote, K., Loman, J.F., Unger, A.E., Biddle, F.G., Snyder, F.F. Biochem. Genet. (1985) [Pubmed]
  11. Cytological localization of adenosine kinase, nucleoside phosphorylase-1, and esterase-10 genes on mouse chromosome 14. Samuelson, L.C., Farber, R.A. Somat. Cell Mol. Genet. (1985) [Pubmed]
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