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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen.

Oxygen-induced pulmonary injury is associated with cell death and a significant inflammatory response. Because transforming growth factor (TGF)-beta is a potent modulator of the immune response, changes in expression of the three TGF-beta (beta 1, beta 2, beta 3) isoforms was determined in lungs of adult mice exposed to > 95% oxygen. TGF-beta 1 immunostaining within cuboidal nonciliated bronchiolar epithelial cells was increased within 3 h of oxygen exposure and continued to increase for 48 h before decreasing to control levels by 72 h. A similar but less marked change that was morphologically consistent with alveolar type II cells was observed in granulated cells. Immunostaining for TGF-beta 2 and TGF-beta 3 revealed a similar change in bronchiolar epithelium with little change observed in the alveolar epithelium. Immunohistochemical changes in TGF-beta expression were not observed in any other pulmonary cells. Northern blot analysis of total lung RNA revealed that expression of the TGF-beta mRNA was not markedly altered over the 72-h exposure period. Exposure to > 95% oxygen resulted in cell type-specific posttranscriptional changes in TGF-beta isoforms in the lung.[1]

References

  1. Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen. O'Reilly, M.A., Staversky, R.J., Flanders, K.C., Johnston, C.J., Finkelstein, J.N. Am. J. Physiol. (1997) [Pubmed]
 
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