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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus.

Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement. Increased 5-HT6 and 5-HT7 receptor expression may provide a basis, in part, for the therapeutic actions of adrenal steroid synthesis inhibitors in resistant depression.[1]

References

  1. Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus. Yau, J.L., Noble, J., Widdowson, J., Seckl, J.R. Brain Res. Mol. Brain Res. (1997) [Pubmed]
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