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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Acute cardiotoxicity of gadolinium-based contrast media: findings in the isolated rat heart.

RATIONALE AND OBJECTIVE: The study was designed to compare acute and direct cardiotoxicity of gadopentetate dimeglumine, gadoteridol injection, and gadodiamide injection. METHODS: Two consecutive injections of contrast material (0.3 to 1.5 mmol/kg body weight) were given to spontaneously beating, isolated rat hearts. Cardiac function was assessed by measuring left ventricular developed pressure (LVDP), perfusion pressure, and electrocardiographic (ECG) parameters. RESULTS: Gadopentetate dimeglumine decreased LVDP, and its first derivatives (+/- dP/dt max) substantially more than gadodiamide injection. Gadoteridol increased these variables. PR and RT intervals lengthened after 1.5 mmol/kg gadopentetate dimeglumine and gadoteridol injection. Bradycardia and ventricular tachyarrhythmias were seen after injection of 1.5 mmol/kg gadopentetate dimeglumine. Except for isolated ventricular premature beats, gadodiamide injection and gadoteridol injection did not provoke any serious arrhythmia. CONCLUSION: Gadopentatate dimeglumine induced negative inotropy and more pronounced ECG disturbances. Gadoteridol injection and gadodiamide injection induced only small changes in left ventricular inotropy and minor electrophysiologic effects.[1]


  1. Acute cardiotoxicity of gadolinium-based contrast media: findings in the isolated rat heart. Akre, B.T., Dunkel, J.A., Hustvedt, S.O., Refsum, H. Academic radiology. (1997) [Pubmed]
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