- Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. Marsters, S.A., Ayres, T.M., Skubatch, M., Gray, C.L., Rothe, M., Ashkenazi, A. J. Biol. Chem. (1997)