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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology.

Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex class I binding peptide, derived from the glycoprotein (GP33 peptide) of lymphocytic choriomeningitis virus (LCMV), specifically tolerized naive cytotoxic T lymphocytes (CTL) when administered three times intraperitoneally in incomplete Freund's adjuvants. However, in the presence of GP33-specific memory CTL in LCMV-primed mice, the same treatment had a general immunosuppressive effect on unrelated third-party antigen-specific T cell responses and caused severe immunopathological damage to the spleen.[1]

References

  1. Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology. Aichele, P., Brduscha-Riem, K., Oehen, S., Odermatt, B., Zinkernagel, R.M., Hengartner, H., Pircher, H. Immunity (1997) [Pubmed]
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