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Gene Review

LASVsSgp2  -  glycoprotein

Lassa virus

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Disease relevance of LASVsSgp2

  • Virus cell entry mediated by LCMV or LFV GP was not affected in rAd-Z-transduced cells, but both virus transcription and replication were strongly and specifically inhibited, which resulted in a dramatic reduction in production of infectious virus [1].
  • Lassa virus is an enveloped virus with glycoprotein spikes on its surface [2].
  • The 5' and 3' terminal nucleotide sequences are conserved and complimentary for 19 nucleotides, the nucleoprotein and glycoprotein genes are arranged in ambisense coding strategy, and the intergenic region contains an inverted complimentary sequence, as do all other arenavirus S RNAs characterized to date [3].
  • To address this hypothesis, transgenic mice were generated that express the nucleoprotein or glycoprotein of lymphocytic choriomeningitis virus (LCMV) as self in oligodendrocytes [4].
  • Expression of cDNA copies of these genes in vaccinia virus vectors demonstrates that C57BL/6 (H2bb) mice mount significant CTL responses to both GP and NP [5].

Psychiatry related information on LASVsSgp2


High impact information on LASVsSgp2


Chemical compound and disease context of LASVsSgp2


Biological context of LASVsSgp2


Anatomical context of LASVsSgp2


Associations of LASVsSgp2 with chemical compounds

  • In this study, we show that the treatment of cells with IFN-gamma enhanced the presentation of gp33-41, whereas presentation of the gp276-286 epitope from the same glycoprotein was markedly reduced [24].
  • We found that class II-associated presentation of endogenously synthesized membrane associated LCMV-GP was efficient and could not be inhibited by chloroquine or leupeptin [21].
  • We found that although CTL- P+ viruses are known to be lymphotropic, mature T and B cells were not required for the generation and selection of the Leu at GP amino acid 260 [25].
  • This phenylalanine (F)-to-leucine (L) change at position 260 of the viral glycoprotein was seen in the vast majority (43 of 47) of the lymphoid isolates, and variants with L at this residue were selected in spleens of persistently infected mice [26].
  • The variant virus carried a single-amino-acid substitution (valine to alanine) at position 35 of the viral glycoprotein [27].

Regulatory relationships of LASVsSgp2


Analytical, diagnostic and therapeutic context of LASVsSgp2


  1. Cells expressing the RING finger Z protein are resistant to arenavirus infection. Cornu, T.I., Feldmann, H., de la Torre, J.C. J. Virol. (2004) [Pubmed]
  2. Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected]. Strecker, T., Eichler, R., Meulen, J., Weissenhorn, W., Dieter Klenk, H., Garten, W., Lenz, O. J. Virol. (2003) [Pubmed]
  3. Nucleotide sequence of the Lassa virus (Josiah strain) S genome RNA and amino acid sequence comparison of the N and GPC proteins to other arenaviruses. Auperin, D.D., McCormick, J.B. Virology (1989) [Pubmed]
  4. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease. Evans, C.F., Horwitz, M.S., Hobbs, M.V., Oldstone, M.B. J. Exp. Med. (1996) [Pubmed]
  5. Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus. Whitton, J.L., Gebhard, J.R., Lewicki, H., Tishon, A., Oldstone, M.B. J. Virol. (1988) [Pubmed]
  6. Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination. Rambukkana, A., Kunz, S., Min, J., Campbell, K.P., Oldstone, M.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Ohashi, P.S., Oehen, S., Buerki, K., Pircher, H., Ohashi, C.T., Odermatt, B., Malissen, B., Zinkernagel, R.M., Hengartner, H. Cell (1991) [Pubmed]
  8. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Lang, K.S., Recher, M., Junt, T., Navarini, A.A., Harris, N.L., Freigang, S., Odermatt, B., Conrad, C., Ittner, L.M., Bauer, S., Luther, S.A., Uematsu, S., Akira, S., Hengartner, H., Zinkernagel, R.M. Nat. Med. (2005) [Pubmed]
  9. Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology. Aichele, P., Brduscha-Riem, K., Oehen, S., Odermatt, B., Zinkernagel, R.M., Hengartner, H., Pircher, H. Immunity (1997) [Pubmed]
  10. Elimination of chronic viral infection by blocking CD27 signaling. Matter, M., Odermatt, B., Yagita, H., Nuoffer, J.M., Ochsenbein, A.F. J. Exp. Med. (2006) [Pubmed]
  11. Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice. Matloubian, M., Somasundaram, T., Kolhekar, S.R., Selvakumar, R., Ahmed, R. J. Exp. Med. (1990) [Pubmed]
  12. endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins. Elder, J.H., Alexander, S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  13. Lassa virus glycoprotein signal peptide displays a novel topology with an extended endoplasmic reticulum luminal region. Eichler, R., Lenz, O., Strecker, T., Eickmann, M., Klenk, H.D., Garten, W. J. Biol. Chem. (2004) [Pubmed]
  14. Site-specific antibodies define a cleavage site conserved among arenavirus GP-C glycoproteins. Buchmeier, M.J., Southern, P.J., Parekh, B.S., Wooddell, M.K., Oldstone, M.B. J. Virol. (1987) [Pubmed]
  15. The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader-derived T cell epitope. Gallimore, A., Schwarz, K., van den Broek, M., Hengartner, H., Groettrup, M. Mol. Immunol. (1998) [Pubmed]
  16. Nucleotide sequence of the glycoprotein gene and intergenic region of the Lassa virus S genome RNA. Auperin, D.D., Sasso, D.R., McCormick, J.B. Virology (1986) [Pubmed]
  17. Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. Lunkenheimer, K., Hufert, F.T., Schmitz, H. J. Clin. Microbiol. (1990) [Pubmed]
  18. Dual role of the lymphocytic choriomeningitis virus intergenic region in transcription termination and virus propagation. Pinschewer, D.D., Perez, M., de la Torre, J.C. J. Virol. (2005) [Pubmed]
  19. Lyssavirus glycoproteins expressing immunologically potent foreign B cell and cytotoxic T lymphocyte epitopes as prototypes for multivalent vaccines. Desmézières, E., Jacob, Y., Saron, M.F., Delpeyroux, F., Tordo, N., Perrin, P. J. Gen. Virol. (1999) [Pubmed]
  20. Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice. Boesen, A., Sundar, K., Coico, R. Clin. Diagn. Lab. Immunol. (2005) [Pubmed]
  21. Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system. Oxenius, A., Bachmann, M.F., Ashton-Rickardt, P.G., Tonegawa, S., Zinkernagel, R.M., Hengartner, H. Eur. J. Immunol. (1995) [Pubmed]
  22. Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Harlan, D.M., Hengartner, H., Huang, M.L., Kang, Y.H., Abe, R., Moreadith, R.W., Pircher, H., Gray, G.S., Ohashi, P.S., Freeman, G.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  23. Prevention of autoimmune disease by retroviral-mediated gene therapy. Ally, B.A., Hawley, T.S., McKall-Faienza, K.J., Kündig, T.M., Oehen, S.U., Pircher, H., Hawley, R.G., Ohashi, P.S. J. Immunol. (1995) [Pubmed]
  24. Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. Basler, M., Youhnovski, N., Van Den Broek, M., Przybylski, M., Groettrup, M. J. Immunol. (2004) [Pubmed]
  25. Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence. Evans, C.F., Borrow, P., de la Torre, J.C., Oldstone, M.B. J. Virol. (1994) [Pubmed]
  26. Molecular basis of organ-specific selection of viral variants during chronic infection. Ahmed, R., Hahn, C.S., Somasundaram, T., Villarete, L., Matloubian, M., Strauss, J.H. J. Virol. (1991) [Pubmed]
  27. In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb. Puglielli, M.T., Zajac, A.J., van der Most, R.G., Dzuris, J.L., Sette, A., Altman, J.D., Ahmed, R. J. Virol. (2001) [Pubmed]
  28. T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs. Kündig, T.M., Hengartner, H., Zinkernagel, R.M. J. Immunol. (1993) [Pubmed]
  29. Simultaneous expression of the Lassa virus N and GPC genes from a single recombinant vaccinia virus. Morrison, H.G., Goldsmith, C.S., Regnery, H.L., Auperin, D.D. Virus Res. (1991) [Pubmed]
  30. Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses. Pushko, P., Geisbert, J., Parker, M., Jahrling, P., Smith, J. J. Virol. (2001) [Pubmed]
  31. Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice. van der Most, R.G., Concepcion, R.J., Oseroff, C., Alexander, J., Southwood, S., Sidney, J., Chesnut, R.W., Ahmed, R., Sette, A. J. Virol. (1997) [Pubmed]
  32. Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes. Oldstone, M.B., Whitton, J.L., Lewicki, H., Tishon, A. J. Exp. Med. (1988) [Pubmed]
  33. Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence. Salvato, M., Borrow, P., Shimomaye, E., Oldstone, M.B. J. Virol. (1991) [Pubmed]
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