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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Glucose metabolism and protective biochemical mechanisms in a rat brain affected by kaolin-induced hydrocephalus.

To clarify glucose metabolism in a hydrocephalic rat brain, substances related to glycolytic metabolism were biochemically measured. Kaolin-induced hydrocephalic rats were sacrificed and lactate dehydrogenase (LDH), LDH isozyme, lactate, adenosine triphosphate (ATP), and isocitrate dehydrogenase (ICDH) were measured in the following regions: cortex, thalamus, midbrain, hippocampus, cerebellum, and pons with medulla. During the development of hydrocephalus, lactate and LDH increased in most regions, the LDH M-subunit increased in the cortex, and ICDH decreased in most regions. However, ATP levels did not change. The increases in lactate, LDH and M-subunit suggested an anaerobic environment in the cell leading to activation of the anaerobic glycolysis. The decrease in ICDH represented a diminution of the tricarboxylic acid cycle. Through these alterations, the ATP level can be kept constant during the course of hydrocephalus, allowing the brain to create a better biochemical milieu.[1]

References

  1. Glucose metabolism and protective biochemical mechanisms in a rat brain affected by kaolin-induced hydrocephalus. Hidaka, M., Matsumae, M., Yamamura, M., Tsugane, R., Sato, O. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1997) [Pubmed]
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