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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Coma from long-term overingestion of isoniazid.

Overingestion of isoniazid can cause confusion, slurred speech, seizures, coma, and death. Most cases of a central nervous system toxic reaction due to isoniazid use result from sudden intentional or accidental overdose. We describe a patient taking 1200 mg of isoniazid daily for 6 weeks who presented to the hospital with confusion and lethargy that progressed to coma. Within 30 minutes of receiving 1 g of intravenous pyridoxine hydrochloride, the patient was fully alert and lucid. The diagnosis of a toxic reaction to isoniazid was delayed by the possibility of concurrent active neurosyphilis and the failure to initially consider isoniazid poisoning in a patient without a history of sudden isoniazid overdose.[1]


  1. Coma from long-term overingestion of isoniazid. Salkind, A.R., Hewitt, C.C. Arch. Intern. Med. (1997) [Pubmed]
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